缺血性卒中pH敏感探针：推进早期检测和准确分级
pH-sensitive probes for ischemic stroke: advancing early detection and accurate grading.
摘要(中文译文)
缺血性卒中（IS）的早期发现和准确评估对于及时治疗和预后评价至关重要。传统的床旁和基于影像学的评估方法，包括美国国立卫生研究院卒中量表（NIHSS）、计算机断层扫描（CT）和磁共振成像（MRI），仍然是急性卒中评估的核心手段，但它们在超急性期存在重要局限性，此时神经功能缺损可能较轻微，结构性影像学改变可能尚未完全显现。在缺血所触发的代谢改变中，组织酸中毒尤其具有提示意义，因为脑灌注不足后pH值迅速下降，并可能在传统影像学异常变得明显之前就揭示缺血性损伤。在本综述中，我们总结了基于pH检测IS的最新进展，重点阐述其在早期诊断和基于生理学的卒中分级方面的潜力。我们讨论了当前的临床和影像学评估方法、缺血相关酸中毒的病理生理基础、新兴的pH检测技术，以及临床转化的主要障碍。最后，我们展望了未来方向，即将pH相关信息与灌注成像、互补生物标志物和人工智能相结合，以支持更全面的缺血性卒中评估框架。
Abstract
Early detection and accurate assessment of ischemic stroke (IS) are essential for timely treatment and prognosis evaluation. Conventional bedside and imaging-based approaches, including the National Institutes of Health Stroke Scale (NIHSS), computed tomography (CT), and magnetic resonance imaging (MRI), remain central to acute stroke assessment, but they have important limitations in the hyperacute stage, when neurological deficits may be subtle and structural imaging changes may not yet be fully apparent. Among the metabolic alterations triggered by ischemia, tissue acidosis is particularly informative because pH declines rapidly after cerebral hypoperfusion and may reveal ischemic injury before conventional imaging abnormalities become obvious. In this review, we summarize recent advances in pH-based detection of IS, with emphasis on its potential for early diagnosis and physiologically informed stroke grading. We discuss current clinical and imaging assessment methods, the pathophysiological basis of ischemia-associated acidosis, emerging pH-detection technologies, and the major barriers to clinical translation. Finally, we outline a future perspective in which pH-related information is integrated with perfusion imaging, complementary biomarkers, and artificial intelligence to support a more comprehensive framework for ischemic stroke assessment.
如何引用
AMA
Chen Zou, Lijun Wang, Yue Wu, Pengfei Yang, Xianfu Meng, Jianmin Liu, et al. pH-sensitive probes for ischemic stroke: advancing early detection and accurate grading.. Frontiers in molecular biosciences. 2026; doi:10.3389/fmolb.2026.1821099.
APA
Chen Zou, Lijun Wang, Yue Wu, Pengfei Yang, Xianfu Meng, Jianmin Liu, et al (2026). pH-sensitive probes for ischemic stroke: advancing early detection and accurate grading.. Frontiers in molecular biosciences. https://doi.org/10.3389/fmolb.2026.1821099
GB/T 7714
Chen Zou, Lijun Wang, Yue Wu, Pengfei Yang, Xianfu Meng, Jianmin Liu, et al. pH-sensitive probes for ischemic stroke: advancing early detection and accurate grading.[J]. Frontiers in molecular biosciences, 2026 doi:10.3389/fmolb.2026.1821099.
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