DKK1在癌症中的作用：分子机制和临床应用的一个实验综述
DKK1 in Cancer: A Bench-to-Bedside Review of Molecular Mechanisms and Clinical Applications.
摘要(中文译文)
Dickkopf-1（DKK1）是一种分泌型糖蛋白，传统上作为经典Wnt/β-catenin信号通路的拮抗剂发挥作用。尽管在特定生物学背景和疾病阶段中，DKK1具有抑癌因子的功能，但越来越多的证据表明，DKK1与多种恶性肿瘤的肿瘤进展、免疫逃逸及治疗耐药密切相关。本综述提供了DKK1在癌症中从基础到临床的全面概述。我们首先阐述了DKK1如何调控Wnt依赖性及Wnt非依赖性通路。从临床角度出发，我们评估了DKK1作为诊断和预后生物标志物的应用潜力。我们进一步讨论了DKK1靶向干预的进展，涵盖从临床试验中的单克隆抗体到新一代治疗模式。最后，我们探讨了临床转化所面临的挑战，并提出了基于DKK1的精准医学的未来发展方向。总之，通过整合临床前研究见解与当前临床数据，本综述为推进癌症中DKK1靶向治疗提供了战略性路线图。
Abstract
Dickkopf-1 (DKK1) is a secreted glycoprotein that traditionally acts as an antagonist of canonical Wnt/β-catenin signaling. Although it functions as a tumor suppressor in some specific biological background and disease stages, growing evidence links DKK1 to tumor progression, immune evasion, and therapy resistance in a variety of multiple malignancies. This review provides a comprehensive bench-to-bedside overview of DKK1 in cancer. We first delineate how DKK1 regulates both Wnt-dependent and Wnt-independent pathways. From a clinical perspective, we evaluate the application potential of DKK1 as a diagnostic and prognostic biomarker. We further discuss the progress of DKK1-targeted interventions, ranging from monoclonal antibodies in clinical trials to next-generation therapeutic modalities. Finally, we discuss the challenges in clinical translation and suggest future directions for DKK1-based precision medicine. In summary, by integrating preclinical insights with current clinical data, this review provides a strategic roadmap for advancing DKK1-targeted therapies in cancer.
如何引用
AMA
Meiheng Sun, Yuzhe Wang, Yihao Zhang, Ziqi Chen, Yuanyuan Yu, Aiping Lu, et al. DKK1 in Cancer: A Bench-to-Bedside Review of Molecular Mechanisms and Clinical Applications.. Cancers. 2026; doi:10.3390/cancers18091375.
APA
Meiheng Sun, Yuzhe Wang, Yihao Zhang, Ziqi Chen, Yuanyuan Yu, Aiping Lu, et al (2026). DKK1 in Cancer: A Bench-to-Bedside Review of Molecular Mechanisms and Clinical Applications.. Cancers. https://doi.org/10.3390/cancers18091375
GB/T 7714
Meiheng Sun, Yuzhe Wang, Yihao Zhang, Ziqi Chen, Yuanyuan Yu, Aiping Lu, et al. DKK1 in Cancer: A Bench-to-Bedside Review of Molecular Mechanisms and Clinical Applications.[J]. Cancers, 2026 doi:10.3390/cancers18091375.
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