原发性干燥综合征患者肠道微生物组和代谢组的多方面特征
Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.
摘要(中文译文)
原发性干燥综合征（pSS）的肠道微生物组及其代谢潜能在很大程度上仍未被探索。本研究对206例pSS患者和355例非pSS对照者的粪便样本进行了全宏基因组鸟枪法测序，并将组成和功能谱分析与血清及粪便代谢组学相结合。pSS与广泛的多界微生物改变相关，包括49种细菌（如副血链球菌、唾液乳杆菌和微小韦荣球菌）、19种真菌（尤其是白色念珠菌）和1，323种病毒。这些特征形成了稳健的界间相关性，并在独立验证队列中实现了高诊断准确性。功能和代谢组学分析揭示，患者中毒素相关和芳香族通路富集，而保护性代谢物耗竭。pSS富集的细菌携带大量免疫原性表位、毒力因子和抗菌药物耐药基因，并在离体条件下诱导促炎反应。总之，这些发现勾勒出pSS的多层面微生物框架，并提示肠道菌群失调与免疫失调之间的机制联系。
Abstract
The gut microbiome and its metabolomic potential in primary Sjögren syndrome (pSS) remain largely unexplored. Here, we perform whole-metagenome shotgun sequencing of fecal samples from 206 pSS patients and 355 non-pSS controls, integrating compositional and functional profiling with serum and fecal metabolomes. pSS is associated with extensive multi-kingdom alterations, including 49 bacterial (e.g., Streptococcus parasanguinis, Ligilactobacillus salivarius, and Veillonella parvula), 19 fungal (notably Candida albicans), and 1,323 viral species. These signatures form robust inter-kingdom correlations and achieve high diagnostic accuracy in an independent validation cohort. Functional and metabolomic analyses reveal enrichment of toxin-related and aromatic pathways and depletion of protective metabolites in patients. pSS-enriched bacteria harbor abundant immunogenic epitopes, virulence factors, and antimicrobial resistance genes, and induce proinflammatory responses ex vivo. Together, these findings outline a multi-faceted microbial framework for pSS and suggest mechanistic links between gut dysbiosis and immune dysregulation.
如何引用
AMA
Changming Chen, Yida Xing, Guorui Xing, Fanxin Zeng, Ning Zheng, Shanshan Sha, et al. Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.. Cell reports. Medicine. 2026; doi:10.1016/j.xcrm.2026.102777.
APA
Changming Chen, Yida Xing, Guorui Xing, Fanxin Zeng, Ning Zheng, Shanshan Sha, et al (2026). Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.. Cell reports. Medicine. https://doi.org/10.1016/j.xcrm.2026.102777
GB/T 7714
Changming Chen, Yida Xing, Guorui Xing, Fanxin Zeng, Ning Zheng, Shanshan Sha, et al. Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.[J]. Cell reports. Medicine, 2026 doi:10.1016/j.xcrm.2026.102777.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出