卵巢衰老：原始卵泡池的维持和激活
Ovarian aging: maintenance and activation of the primordial follicle pool.
摘要(中文译文)
作为女性最早衰老的器官，卵巢经历功能衰退和结构衰老，从而驱动生殖系统改变。这一过程的核心是原始卵泡——女性生殖细胞不可再生的储备库，也是卵母细胞发育的唯一来源。原始卵泡池在出生前即已建立，数量固定，出生后无法再生，是决定生育潜力和生殖寿命的基础生物学储备。一旦开始耗竭便不可逆转，直接限制生殖窗口并影响卵巢内分泌功能。因此，本文简要总结了原始卵泡发育的最新研究进展，深入分析了原始卵泡的休眠与激活机制以及相关并发症的治疗方法。这项工作对于理解生殖衰老、防治生殖内分泌疾病以及开发新型生育策略具有重要意义，为理解原始卵泡的生物学机制和潜在应用提供了有价值的参考。
Abstract
As the earliest aging organ in females, the ovary undergoes functional decline and structural senescence that drive reproductive system alterations. Central to this process is the primordial follicle-the non-renewable reserve of female germ cells and the sole source for oocyte development. The primordial follicle pool is established prenatally, fixed in quantity, and cannot regenerate after birth, serving as the fundamental biological reserve that determines both fertility potential and reproductive lifespan. Once depletion begins, it is irreversible, directly limiting the reproductive window and influencing ovarian endocrine function. Therefore, this review briefly summarizes the latest research progress on primordial follicle development, providing an in-depth analysis of primordial follicle dormancy and activation mechanisms as well as therapeutic approaches for associated complications. This work holds significant implications for understanding reproductive aging, preventing and treating reproductive endocrine disorders, and developing novel fertility strategies, offering valuable references for comprehending the biological mechanisms and potential applications of primordial follicles.
如何引用
AMA
Qian Wang, Guodong Zhao, Jiaqi Zhou. Ovarian aging: maintenance and activation of the primordial follicle pool.. Journal of ovarian research. 2026; doi:10.1186/s13048-026-02116-8.
APA
Qian Wang, Guodong Zhao, Jiaqi Zhou (2026). Ovarian aging: maintenance and activation of the primordial follicle pool.. Journal of ovarian research. https://doi.org/10.1186/s13048-026-02116-8
GB/T 7714
Qian Wang, Guodong Zhao, Jiaqi Zhou. Ovarian aging: maintenance and activation of the primordial follicle pool.[J]. Journal of ovarian research, 2026 doi:10.1186/s13048-026-02116-8.
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