用于肿瘤分子成像和治疗的神经降压素受体1靶向分子探针的进展
Advances in neurotensin receptor 1-targeted molecular probes for tumor molecular imaging and therapy.
摘要(中文译文)
神经降压素受体1（NTS1）是内源性肽神经降压素（NT）的高亲和力G蛋白偶联受体（GPCR）。NTS1在多种恶性肿瘤中过表达，是精准诊疗的重要靶点。近年来，NTS1靶向分子探针取得了显著进展，提高了分子影像学的灵敏度和特异性，包括荧光成像、正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）以及PET/荧光多模态成像，同时在疗效评估和治疗决策方面也展现出前景。与此同时，将分子影像与靶向治疗相结合的治疗诊断策略实现了患者分层、个体化治疗和疗效监测的闭环工作流程。在本综述中，我们总结了NTS1靶向分子探针的最新进展，特别着重于其在肿瘤分子影像、放射性配体治疗以及诊疗一体化管理中的临床应用。我们整合了临床前模型和早期人体研究的证据，并概述了目前限制其临床转化的主要挑战。总体而言，本综述旨在为NTS1靶向分子探针在精准肿瘤学中的持续发展提供有益参考。
Abstract
Neurotensin receptor 1 (NTS1) is a high-affinity G protein-coupled receptor (GPCR) for the endogenous peptide neurotensin (NT). NTS1 is overexpressed across multiple malignancies and is an important target for precision theranostics. In recent years, NTS1-targeted molecular probes have advanced considerably, improving the sensitivity and specificity of molecular imaging, including fluorescence imaging, positron emission tomography (PET), single-photon emission computed tomography (SPECT), and multimodal PET/fluorescence imaging, while also showing promise for response assessment and therapeutic decision-making. In parallel, theranostic strategies that integrate molecular imaging with targeted therapy enable a closed-loop workflow for patient stratification, individualized treatment, and response monitoring. In this review, we summarize recent advances in NTS1-targeted molecular probes, with particular emphasis on their clinical applications in tumor molecular imaging, radioligand therapy, and integrated diagnostic and therapeutic management. We integrate evidence from preclinical models and early human studies and outline the main challenges that currently limit their clinical translation. Overall, this review aims to provide a useful reference for the continued development of NTS1-targeted molecular probes in precision oncology.
如何引用
AMA
Chengkuan Liu, Jiang Fu, Shengjie Tang, Haiyang Hu, Haiyang Guo, Tao Liu, et al. Advances in neurotensin receptor 1-targeted molecular probes for tumor molecular imaging and therapy.. Frontiers in oncology. 2026; doi:10.3389/fonc.2026.1817036.
APA
Chengkuan Liu, Jiang Fu, Shengjie Tang, Haiyang Hu, Haiyang Guo, Tao Liu, et al (2026). Advances in neurotensin receptor 1-targeted molecular probes for tumor molecular imaging and therapy.. Frontiers in oncology. https://doi.org/10.3389/fonc.2026.1817036
GB/T 7714
Chengkuan Liu, Jiang Fu, Shengjie Tang, Haiyang Hu, Haiyang Guo, Tao Liu, et al. Advances in neurotensin receptor 1-targeted molecular probes for tumor molecular imaging and therapy.[J]. Frontiers in oncology, 2026 doi:10.3389/fonc.2026.1817036.
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