左心室辅助装置和右心功能障碍：影响机制、评估方法以及预防和管理综述
Left ventricular assist devices and right heart dysfunction: a review of impact mechanisms, evaluation methods, and prevention and management.
摘要(中文译文)
左心室辅助装置（LVADs）已成为终末期心力衰竭患者的重要治疗选择，显著改善了左心室功能和患者生存率。然而，LVAD植入对右心功能的影响复杂，右心功能障碍是影响患者预后和生活质量的关键因素。本文系统综述了LVAD与右心功能的关系，重点关注右心功能在LVAD患者中的重要性、评估方法、影响机制以及预防和管理策略。此外，还介绍了新兴技术和未来研究方向，为临床实践提供参考。研究表明，全面评估右心功能对于预测术后右心功能障碍风险至关重要。LVAD植入对右心功能的影响机制复杂，包括前负荷和后负荷的变化以及心室相互依赖。右心功能障碍的预防和管理需要综合措施，包括术前优化、精细的术中操作、密切的术后监测和多学科团队协作。改进的LVAD设计、双心室辅助装置、基因治疗和个性化医疗等新兴技术为降低右心功能障碍的发生率提供了新的希望。右心功能在LVAD治疗中具有不可否认的重要性。通过全面评估、预防和管理右心功能，以及应用新技术，有望降低右心功能障碍的发生率，改善LVAD患者的预后和生活质量。未来需要更多高质量研究以推动新兴技术的临床应用，为终末期心力衰竭患者提供更全面的治疗选择。
Abstract
Left ventricular assist devices (LVADs) have become an important treatment option for patients with end-stage heart failure, significantly improving left ventricular function and patient survival rates. However, LVAD implantation has complex effects on right heart function, and right heart dysfunction is a critical factor affecting patient prognosis and quality of life. This article systematically reviews the relationship between LVADs and right heart function, focusing on the importance of right heart function in LVAD patients, evaluation methods, impact mechanisms, and prevention and management strategies. Additionally, it introduces emerging technologies and future research directions to provide references for clinical practice. Studies have shown that comprehensive evaluation of right heart function is crucial for predicting the risk of postoperative right heart dysfunction. The impact mechanisms of LVAD implantation on right heart function are complex, including changes in preload and afterload and ventricular interdependence. Prevention and management of right heart dysfunction require comprehensive measures, including preoperative optimization, meticulous intraoperative procedures, close postoperative monitoring, and multidisciplinary team collaboration. Emerging technologies such as improved LVAD designs, biventricular assist devices, gene therapy, and personalized medicine offer new hope for reducing the incidence of right heart dysfunction. Right heart function holds undeniable importance in LVAD therapy. Through comprehensive evaluation, prevention, and management of right heart function, as well as the application of new technologies, it is expected to reduce the incidence of right heart dysfunction and improve the prognosis and quality of life of LVAD patients. More high-quality research is needed in the future to promote the clinical application of emerging technologies and provide more comprehensive treatment options for patients with end-stage heart failure.
如何引用
AMA
Zhiwei Fan, Pengyu Zhou, Shiliang Li, Shaopeng Cheng, Yumeng Wang, Jun Pan, et al. Left ventricular assist devices and right heart dysfunction: a review of impact mechanisms, evaluation methods, and prevention and management.. Journal of cardiothoracic surgery. 2026; doi:10.1186/s13019-026-04003-1.
APA
Zhiwei Fan, Pengyu Zhou, Shiliang Li, Shaopeng Cheng, Yumeng Wang, Jun Pan, et al (2026). Left ventricular assist devices and right heart dysfunction: a review of impact mechanisms, evaluation methods, and prevention and management.. Journal of cardiothoracic surgery. https://doi.org/10.1186/s13019-026-04003-1
GB/T 7714
Zhiwei Fan, Pengyu Zhou, Shiliang Li, Shaopeng Cheng, Yumeng Wang, Jun Pan, et al. Left ventricular assist devices and right heart dysfunction: a review of impact mechanisms, evaluation methods, and prevention and management.[J]. Journal of cardiothoracic surgery, 2026 doi:10.1186/s13019-026-04003-1.
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