通过自凝胶化和相分离一步形成分级水凝胶贴片，通过单侧组织粘附、抗菌和抗炎特性促进口腔溃疡治疗
One-Step Formation of Hierarchical Hydrogel Patch by Self-Gelling and Phase Separation Promotes Oral Ulcer Treatment via One-Sided Tissue Adhesion, Antibacterial, and Anti-Inflammatory Properties.
摘要(中文译文)
传统口腔溃疡药物的治疗效果有限，原因在于其合成路线复杂、湿组织黏附力弱以及生物活性差。为解决这些问题，本研究开发了一种由聚丙烯酸（PAA）、季铵化壳聚糖（QCS）和葛根素（PUE）组成的新型可喷雾自凝胶粉末，该粉末能够快速吸收唾液，并通过氢键和离子相互作用在溃疡部位原位形成水凝胶贴片。更重要的是，该水凝胶贴片在过量流动唾液作用下会发生相分离，并自发转化为具有非黏附性顶层PUE层和黏附性底层PAA/QCS/PUE层的分级结构，从而避免水凝胶贴片与除口腔溃疡部位以外的邻近组织发生非预期黏附。此外，该分级水凝胶贴片还表现出优异的抗菌和抗炎特性，这已通过其对多种细菌的广谱抗菌性能、高活性氧（ROS）清除能力以及促进巨噬细胞从M1型向M2型转化所证实。得益于良好单侧组织黏附性、抗菌和抗炎特性之间的协同作用，使用自凝胶PAA/QCS/PUE粉末可有效实现兔口腔黏膜缺损的体内创面愈合。
Abstract
The therapeutic effect of traditional oral ulcer medications is limited, due to their complex synthetic routes, weak wet tissue adhesion, and poor bioactivity. To address these issues, a novel sprayable self-gelling powder composed of polyacrylic acid (PAA), quaternized chitosan (QCS) and puerarin (PUE) is developed, which can absorb saliva quickly and form a hydrogel patch in situ at the ulcer site through hydrogen bonding and ionic interactions. More importantly, this hydrogel patch undergoes phase separation under excessive flowing saliva and spontaneously converts into a hierarchical structure with a non-adhesive top PUE layer and an adhesive bottom PAA/QCS/PUE layer, avoiding unexpected adhesion between the hydrogel patch and adjacent tissues except oral ulcer site. In addition, this hierarchical hydrogel patch also exhibits excellent antibacterial and anti-inflammatory properties, as proven by the universal antibacterial performance toward multiple bacteria, high reactive oxygen species (ROS) scavenging capacity and promotion of macrophages from M1 to M2 types. Owing to the synergism among good one-sided tissue adhesion, antibacterial and anti-inflammatory properties, in vivo wound healing of rabbit oral mucosa defect can be realized efficiently using self-gelling PAA/QCS/PUE powders.
如何引用
AMA
Hongbo Yu, Zhenan Li, Chuhan Lv, Zibo Liu, Hua Dong. One-Step Formation of Hierarchical Hydrogel Patch by Self-Gelling and Phase Separation Promotes Oral Ulcer Treatment via One-Sided Tissue Adhesion, Antibacterial, and Anti-Inflammatory Properties.. Advanced healthcare materials. 2026; doi:10.1002/adhm.71232.
APA
Hongbo Yu, Zhenan Li, Chuhan Lv, Zibo Liu, Hua Dong (2026). One-Step Formation of Hierarchical Hydrogel Patch by Self-Gelling and Phase Separation Promotes Oral Ulcer Treatment via One-Sided Tissue Adhesion, Antibacterial, and Anti-Inflammatory Properties.. Advanced healthcare materials. https://doi.org/10.1002/adhm.71232
GB/T 7714
Hongbo Yu, Zhenan Li, Chuhan Lv, Zibo Liu, Hua Dong. One-Step Formation of Hierarchical Hydrogel Patch by Self-Gelling and Phase Separation Promotes Oral Ulcer Treatment via One-Sided Tissue Adhesion, Antibacterial, and Anti-Inflammatory Properties.[J]. Advanced healthcare materials, 2026 doi:10.1002/adhm.71232.
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