中国广东省养猪场高致病性格塔病毒的再次出现和特征
Re-Emergence and Characterization of a Highly Pathogenic Getah Virus on a Pig Farm in Guangdong Province, China.
摘要(中文译文)
盖塔病毒（GETV）是一种蚊媒病毒，能够感染多种具有重要经济价值的动物物种，具有潜在的流行风险。2024年5月，中国广东省河源市某猪场出现母猪繁殖障碍和新生仔猪腹泻。采集的6份血液样本中，3份GETV检测呈强阳性，阳性率为50%。此外，成功分离并鉴定出一株GETV毒株（命名为GDHYLC2024）。GDHYLC2024在Vero细胞中的病毒滴度为10 TCID/mL。其基因组全长为11,688个碱基。有趣的是，与GDHYLC23相比，该毒株在3'非编码区没有独特的32个核苷酸重复插入。然而，系统发育分析显示GDHYLC2024与GDHYLC23均属于基因III型。动物感染实验表明，GDHYLC2024毒株对4日龄仔猪具有高致病性，可引起明显的临床症状，包括发热、精神沉郁、厌食、眶周水肿、共济失调，感染组5头仔猪中有3头死亡。本研究报道了GETV在中国广东省同一地区的再次出现。上述发现表明，GETV持续对养殖猪的健康构成威胁，并具有遗传多样性。
Abstract
Getah virus (GETV), a mosquito-borne virus capable of infecting multiple economically important animal species, poses a potential epidemic risk. In May 2024, one pig farm from Heyuan, Guangdong Province, China, suffered reproductive disorders in sows and diarrhea in newborn piglets. Out of the six blood samples that were collected, three tested strongly positive for GETV, yielding a positivity rate of 50%. Moreover, a GETV strain (designated GDHYLC2024) was successfully isolated and identified. The viral titer of GDHYLC2024 was 10 TCID/mL in Vero cells. Its genome was composed of 11,688 bases in length. Interestingly, compared with GDHYLC23, it had no unique 32-nucleotide repeat insertion in 3' non-coding region. However, phylogenetic analysis showed that GDHYLC2024 and GDHYLC23 clustered in genotype III. Animal infection experiments demonstrated that the GDHYLC2024 strain was highly pathogenic to 4-day-old piglets, which caused obvious clinical symptoms including fever, depression, anorexia, periorbital edema, ataxia, and three deaths out of a total of five individuals in the infection group. This study reported re-emergence of GETV in the same region of Guangdong Province, China. The above findings suggest that GETV continuously poses a threat to farm pig's health and has genetic diversity.
如何引用
AMA
Handuo Jia, Huahua Kang, Pinpin Chu, Tongqi Wang, Yulin Guo, Jitong Chen, et al. Re-Emergence and Characterization of a Highly Pathogenic Getah Virus on a Pig Farm in Guangdong Province, China.. Microorganisms. 2026; doi:10.3390/microorganisms14040846.
APA
Handuo Jia, Huahua Kang, Pinpin Chu, Tongqi Wang, Yulin Guo, Jitong Chen, et al (2026). Re-Emergence and Characterization of a Highly Pathogenic Getah Virus on a Pig Farm in Guangdong Province, China.. Microorganisms. https://doi.org/10.3390/microorganisms14040846
GB/T 7714
Handuo Jia, Huahua Kang, Pinpin Chu, Tongqi Wang, Yulin Guo, Jitong Chen, et al. Re-Emergence and Characterization of a Highly Pathogenic Getah Virus on a Pig Farm in Guangdong Province, China.[J]. Microorganisms, 2026 doi:10.3390/microorganisms14040846.
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