老年冠心病患者虚弱与抑郁之间的关联：系统综述和荟萃分析
Association between frailty and depression in older adults with coronary heart disease: a systematic review and meta-analysis.
摘要(中文译文)
衰弱与抑郁在老年冠心病（CHD）患者中经常共存，且各自均与不良结局相关。然而，其在该人群中关联的强度与性质尚未得到系统量化。我们系统检索了PubMed、Embase、Web of Science及其他主要数据库自建库至2025年4月的观察性研究，这些研究探讨了成人CHD患者中衰弱与抑郁之间的关联。两名评价者独立筛选研究、提取数据，并分别采用纽卡斯尔-渥太华量表（用于队列研究）和AHRQ清单（用于横断面研究）评估质量。横断面研究和队列研究均符合纳入标准。采用随机效应模型计算合并比值比（OR）及其95%置信区间（CI），在可获得时优先采用校正后的估计值。采用统计量量化异质性。预设按地区、研究设计和评估工具进行亚组分析。在筛选的2,160条记录中，6项研究符合纳入标准，共纳入2,628例CHD患者。所有纳入研究均聚焦于老年人（平均/中位年龄≥60岁），反映了该人群当前的证据基础。荟萃分析显示，衰弱与抑郁之间存在显著正相关（合并OR=2.45；95% CI：1.22-4.92），异质性较大（=90%）。按研究设计分析时，该关联在队列研究中似乎更为显著（OR=3.92；95% CI：1.66-9.27；=71%），而在横断面研究中相对较弱（OR=1.91；95% CI：1.02-3.58；=74%）。衰弱与抑郁在老年CHD患者中显著相关，支持整合筛查策略。然而，鉴于横断面数据占主导、异质性较高且队列证据有限，仍需前瞻性研究以确立时间先后关系并更好地支持因果推断。https://www.crd.york.ac.uk/PROSPERO/view/CRD420251036929，PROSPERO（CRD420Ò51036929）。
Abstract
Frailty and depression frequently co-occur in older patients with coronary heart disease (CHD) and are each associated with adverse outcomes. However, the strength and nature of their association in this population have not been systematically quantified. We systematically searched PubMed, Embase, and Web of Science and other major databases from inception to April 2025 for observational studies examining the association between frailty and depression in adults with CHD. Two reviewers independently screened studies, extracted data, and assessed quality using the Newcastle-Ottawa Scale for cohort studies and the AHRQ checklist for cross-sectional studies. Both cross-sectional and cohort studies were eligible. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model, prioritizing adjusted estimates where available. Heterogeneity was quantified using the statistic. Subgroup analyses were planned by region, study design and assessment tool. Of 2,160 records screened, 6 studies met the inclusion criteria, comprising 2,628 patients with CHD. All included studies focused on older adults (mean/median age ≥60 years), reflecting the current evidence base in this population. Meta-analysis showed a significant positive association between frailty and depression (pooled OR = 2.45; 95% CI: 1.22-4.92), with substantial heterogeneity ( = 90%). When analyzed by study design, the association appeared more pronounced in cohort studies (OR = 3.92; 95% CI: 1.66-9.27; = 71%) than in cross-sectional studies (OR = 1.91; 95% CI: 1.02-3.58; = 74%). Frailty and depression are significantly associated in older adults with CHD, supporting integrated screening approaches. However, given the predominance of cross-sectional data, high heterogeneity, and limited cohort evidence, prospective studies are needed to establish temporality and better inform causal inference. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251036929, PROSPERO (CRD420Ò51036929).
如何引用
AMA
Yuan Chen, Zhaoxia Zhang, Yuanling Tang, Shixia Zhang, Yaling Huang, Wenting Chai, et al. Association between frailty and depression in older adults with coronary heart disease: a systematic review and meta-analysis.. Frontiers in public health. 2026; doi:10.3389/fpubh.2026.1737823.
APA
Yuan Chen, Zhaoxia Zhang, Yuanling Tang, Shixia Zhang, Yaling Huang, Wenting Chai, et al (2026). Association between frailty and depression in older adults with coronary heart disease: a systematic review and meta-analysis.. Frontiers in public health. https://doi.org/10.3389/fpubh.2026.1737823
GB/T 7714
Yuan Chen, Zhaoxia Zhang, Yuanling Tang, Shixia Zhang, Yaling Huang, Wenting Chai, et al. Association between frailty and depression in older adults with coronary heart disease: a systematic review and meta-analysis.[J]. Frontiers in public health, 2026 doi:10.3389/fpubh.2026.1737823.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出