减少霉菌毒素污染和提高食品系统可持续性的合成生物学方法

摘要(中文译文)

极端气候事件正在加剧真菌毒素（mycotoxin）污染——即丝状真菌产生的毒性次级代谢产物——对人类和动物健康构成严重威胁，并造成全球重大粮食损失。合成生物学为真菌毒素消减及食品与食品加工副产物的可持续利用提供了变革性解决方案。真菌毒素控制的关键进展整合了人工智能与多组学技术，以开发识别元件、抗菌剂和降解酶，从而实现对产毒真菌和真菌毒素的快速检测与有效控制。可持续性应用涵盖三个领域：通过工程化微生物升级循环实现副产物增值、新型可食用材料（如真菌蛋白），以及提高作物产量和抗病性，凸显了CRISPR多重编辑和微生物细胞工厂等新兴技术。总体而言，本研究强调了合成生物学在真菌毒素降解及食品及其副产物增值转化中的关键作用，推动迈向粮食安全和循环生物经济。

Abstract

Extreme climate events are escalating mycotoxin contamination-toxic secondary metabolites from filamentous fungi-posing severe threats to human/animal health and causing significant global food losses. Synthetic biology offers transformative solutions for mycotoxin mitigation and sustainable utilization of food and by-products from food processing. Key advances in mycotoxin control integrate artificial intelligence and multi-omics to develop recognition elements, antimicrobial agents, and degrading enzymes, which enable rapid detection and effective control of both mycotoxin-producing fungi and mycotoxins. Sustainability applications span three domains: by-product valorization via engineered microbial upcycling, new edible materials (e.g., fungal proteins), and enhancement of crop yield and disease resistance, highlighting emerging technologies like CRISPR-based multiplex editing and microbial cell factories. Collectively, this work underscores synthetic biology's critical role in mycotoxin degradation and value-added conversion of food and its by-products, driving progress toward food security and circular bioeconomy.

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