转录因子RIN和NOR在果实成熟的起始和进展中既有冗余的作用，也有特定的作用
The transcription factors RIN and NOR have both redundant and specific roles in the initiation and progression of fruit ripening.
摘要(中文译文)
转录因子RIPENING-INHIBITOR（RIN）和NONRIPENING（NOR）是番茄（Solanum lycopersicum）果实成熟的关键调控因子。然而，最初描述的自发突变等位基因rin和nor被证明是功能获得型突变体，这促使人们重新评估RIN和NOR在番茄果实成熟中的作用。在此，我们表明slnor slrin双突变体（NOR和RIN的双纯合功能缺失突变体）表现出果实成熟的完全停止，揭示了NOR和RIN以冗余但差异化的方式调控果实成熟。除了作为激活因子外，NOR和RIN在抑制光合作用相关基因方面也是必不可少的。此外，在成熟启动阶段，NOR通过结合RIN的启动子激活RIN的表达。在呼吸跃变型乙烯产生之后，RIN抑制NOR的表达。这种时序性相互作用对于果实成熟过程中脱落酸（ABA）和乙烯生物合成的调控至关重要。有趣的是，NOR和RIN不形成转录复合体。总之，我们的研究结果提供了对NOR和RIN参与果实成熟调控网络的见解，并揭示了它们在成熟激素乙烯和ABA之间交互对话中的作用。
Abstract
The transcription factors (TFs) RIPENING-INHIBITOR (RIN) and NONRIPENING (NOR) are key regulators of fruit ripening in tomato (Solanum lycopersicum) fruit ripening. However, the spontaneous rin and nor alleles that were first described were demonstrated to be gain-of-function mutants, prompting a reevaluation of the roles of RIN and NOR in tomato fruit ripening. Here, we show that the slnor slrin double mutant (a double homozygous loss-of-function mutant of NOR and RIN) exhibits a complete cessation of fruit ripening, revealing that NOR and RIN redundantly but differentially regulate fruit ripening. Besides serving as activators, NOR and RIN are essential in suppressing genes related to photosynthesis. Additionally, at the initiation of ripening, NOR activates RIN expression by binding to its promoter. Following climacteric ethylene production, RIN represses NOR expression. This temporal interaction is crucial for the regulation of abscisic acid (ABA) and ethylene biosynthesis during fruit ripening. Interestingly, NOR and RIN do not form a transcriptional complex. Collectively, our findings provide insights into the regulatory network involving NOR and RIN in fruit ripening and uncover their roles in the crosstalk between the ripening hormones ethylene and ABA.
如何引用
AMA
Ying Gao, Yujing Lin, Ting Yang, Hanxiao Bian, Jingyu Wang, Shan Li, et al. The transcription factors RIN and NOR have both redundant and specific roles in the initiation and progression of fruit ripening.. The Plant cell. 2026; doi:10.1093/plcell/koag126.
APA
Ying Gao, Yujing Lin, Ting Yang, Hanxiao Bian, Jingyu Wang, Shan Li, et al (2026). The transcription factors RIN and NOR have both redundant and specific roles in the initiation and progression of fruit ripening.. The Plant cell. https://doi.org/10.1093/plcell/koag126
GB/T 7714
Ying Gao, Yujing Lin, Ting Yang, Hanxiao Bian, Jingyu Wang, Shan Li, et al. The transcription factors RIN and NOR have both redundant and specific roles in the initiation and progression of fruit ripening.[J]. The Plant cell, 2026 doi:10.1093/plcell/koag126.
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