使用广角光学相干断层扫描对患有或不患有糖尿病视网膜病变的糖尿病患者进行视网膜缺血的半自动分析
Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.
摘要(中文译文)
目的：本研究评估了糖尿病视网膜病变（DR）三个分期（无DR（0期）、非增殖性DR（1期）和增殖性DR（2期））糖尿病患者视网膜非灌注区（RNPAs）以及浅层（SCP）和深层（DCP）毛细血管丛血管密度（VD）。方法：纳入39例糖尿病患者的39只右眼，接受3×3 mm和15×15 mm光学相干断层扫描血管成像（OCTA）扫描。使用半自动化软件量化RNPAs和VD。分析其与全身及眼部因素的相关性。结果：6只眼处于0期，25只眼处于1期，8只眼处于2期。15×15 mm OCTA扫描的平均RNPAs和VD在三个DR分期之间差异有统计学意义。DR分期与SCP（CC=0.42；=0.04）和DCP（CC=0.60；=0.004）中的RNPA均呈正相关。相反，DCP中的VD与DR严重程度呈负相关（CC=-0.51；=0.0018）。既往接受过周边激光治疗的眼在广角扫描中显示RNPAs显著更大、VD更低。黄斑水肿与3×3 mm OCTA上SCP中RNPA增加和VD降低相关（<0.001）。OCTA参数与全身因素（如高血压、肾病）之间未观察到显著关联。结论：半自动化OCTA分析显示的视网膜缺血与DR分期、周边激光治疗和黄斑水肿呈正相关。与全身因素缺乏关联凸显了局部眼部改变在DR进展中的关键作用。
Abstract
PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0), non-proliferative DR (stage 1), and proliferative DR (stage 2).MethodsThirty-nine right eyes of 39 diabetic patients were included and underwent 3 × 3 mm and 15 × 15 mm Optical Coherence Tomography Angiography (OCTA) scans. A semiautomated software was utilized to quantify RNPAs and VD. Correlations with systemic and ocular factors were analyzed.ResultsSix eyes were in stage 0, 25 eyes were in stage 1 and 8 eyes were in stage 2. Mean RNPAs and VD from 15 × 15 mm OCTA scans differed significantly across the three DR stages. A positive correlation was found between DR stage and RNPA in both SCP (CC = 0.42; = 0.04) and DCP (CC = 0.60; = 0.004). Conversely, VD in DCP was negatively correlated with DR severity (CC = -0.51; = 0.0018). Eyes with prior peripheral laser treatment showed significantly larger RNPAs and lower VD in wide-field scans. Macular edema was associated with increased RNPA and reduced VD in the SCP on 3 × 3 mm OCTA ('s < 0.001). No significant associations were observed between OCTA parameters and systemic factors (e.g., hypertension, nephropathy).ConclusionSemiautomated OCTA analysis of retinal ischemia correlates positively with DR stage, peripheral laser treatment, and macular edema. The lack of association with systemic factors highlights the critical role of local ocular changes in DR progression.
如何引用
AMA
Toto Lisa, Chiarelli Antonio Maria, Belloni Baroni Luca, Passamonti Marzia, Quarta Alberto, Ruggeri Maria Ludovica, et al. Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.. European journal of ophthalmology. 2026; doi:10.1177/11206721261444772.
APA
Toto Lisa, Chiarelli Antonio Maria, Belloni Baroni Luca, Passamonti Marzia, Quarta Alberto, Ruggeri Maria Ludovica, et al (2026). Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.. European journal of ophthalmology. https://doi.org/10.1177/11206721261444772
GB/T 7714
Toto Lisa, Chiarelli Antonio Maria, Belloni Baroni Luca, Passamonti Marzia, Quarta Alberto, Ruggeri Maria Ludovica, et al. Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.[J]. European journal of ophthalmology, 2026 doi:10.1177/11206721261444772.
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