红光和紫光的眼透射：对光基近视治疗的见解
Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.
摘要(中文译文)
本研究旨在测定红光和紫光在眼组织中的透射情况，以了解基于光的近视控制仪器所发出的光有多少能够到达各层组织。取新鲜猪眼（n = 5，眼轴长度 = 22.40 ± 1.52 mm）进行解剖，分离出角膜、晶状体、视网膜、视网膜色素上皮（RPE）/脉络膜及巩膜。分别测量红色激光（654 nm）、红色发光二极管（LED；660 nm）和紫色LED（396 nm）的光透射率。使用辐射计对透射率进行定量。采用单因素方差分析及Bonferroni事后检验比较平均透射率值。与红色激光和红色LED相比，紫色LED发出的光在角膜、晶状体和视网膜的透射率均显著较低（P均 < 0.05）。红色激光的光相对于红色LED的光，其视网膜透射率降低（P = 0.03）。考虑经眼前节结构的累积透射后，入射至后巩膜的光功率分别为：红色激光（麦克斯韦照明）1.66 µW（0.6%），红色激光0.37 µW（0.6%），红色LED 2.79 µW（0.9%），紫色LED 5.85 µW（0.1%）。红光在眼组织中的穿透力强于紫光。紫光被角膜和晶状体更强烈地衰减，表明其到达视网膜的量有限。脉络膜对所有光源均构成主要屏障。了解红光和紫光在眼组织中的透射效率，是寻找光介导近视控制策略背后生物学通路机制关联的关键第一步。
Abstract
The purpose of this study was to determine transmission of red and violet light through ocular tissues, providing insight into how much light from light-based myopia control instruments reaches each tissue. Fresh porcine eyes (n = 5, axial length = 22.40 ± 1.52 mm) were dissected to isolate the cornea, lens, retina, retinal pigment epithelium (RPE)/choroid, and sclera. Light transmission was measured for a red laser (654 nm), red light-emitting diodes (LEDs; 660 nm), and violet LEDs (396 nm). Transmission was quantified using a radiometer. Mean transmission values were compared using 1-way ANOVA with Bonferroni post hoc tests. Corneal, lenticular, and retinal transmission were significantly lower for light emitted from violet LEDs compared with red laser and red LEDs (P < 0.05 for all). Light from the red laser showed reduced retinal transmission relative to the light from the red LEDs (P = 0.03). Power of light incident on the posterior sclera, considering cumulative transmission through the anterior ocular structures, was 1.66 µW (0.6%) for the red laser (with Maxwellian), 0.37 µW (0.6%) for the red laser, 2.79 µW (0.9%) for red LEDs, and 5.85 µW (0.1%) for violet LEDs. Red light exhibited greater penetration through ocular tissues than violet light. Violet light was more strongly attenuated by the cornea and lens, demonstrating limited retinal delivery. The choroid acted as a major barrier to all light sources. Understanding transmission efficiency of red and violet light through ocular tissues is a critical first step in finding a mechanistic link to biological pathways underlying light-mediated myopia control strategies.
如何引用
AMA
Jacinth J Priscilla, Krista M Beach, Rakesh Maldoddi, Alexander W Schill, Lisa A Ostrin. Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.. Translational vision science & technology. 2026; doi:10.1167/tvst.15.4.21.
APA
Jacinth J Priscilla, Krista M Beach, Rakesh Maldoddi, Alexander W Schill, Lisa A Ostrin (2026). Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.. Translational vision science & technology. https://doi.org/10.1167/tvst.15.4.21
GB/T 7714
Jacinth J Priscilla, Krista M Beach, Rakesh Maldoddi, Alexander W Schill, Lisa A Ostrin. Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.[J]. Translational vision science & technology, 2026 doi:10.1167/tvst.15.4.21.
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