妊娠期糖尿病患者omega-3和omega-6脂肪酸的胎盘转运功能障碍
Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.
摘要(中文译文)
妊娠期糖尿病（GDM）会影响脂肪酸（FA）从母体向胎儿的转运。然而，具体的转运改变仍不明确。本研究探讨了GDM中脂肪酸从母体向胎儿的转运。收集了20例健康妊娠（正常组）和20例接受血糖管理的GDM妊娠（GDM组）的母体血清、脐带血清和胎盘组织。采用气相色谱-质谱法对51种脂肪酸进行定量分析。使用Student's t检验或Mann-Whitney U检验（视情况而定）比较两组间脂肪酸组成的胎盘/母体比值和胎儿/胎盘比值。GDM中脂肪酸谱的浓度和组成均发生改变。GDM组中顺式-11,14,17-二十碳三烯酸的胎盘/母体比值（GDM vs 正常：0.648 vs 0.484，= 0.001）、顺式-5,8,11,14,17-二十碳五烯酸（0.449 vs 0.338，= 0.048）、顺式-13,16-二十二碳二烯酸（DDA，1.436 vs 1.187，= 0.047）、棕榈反油酸（2.882 vs 2.272，= 0.023）、岩芹反油酸（2.177 vs 1.746，= 0.004）和反式亚油酸（1.770 vs 1.423，= 0.014）显著升高，而反式-10-十九碳烯酸的比值（0.537 vs 0.799，< 0.001）降低。GDM组中总omega-6长链多不饱和脂肪酸（LC PUFA）的胎儿/胎盘比值（0.545 vs 0.590，= 0.002）以及DDA（4.031 vs 4.951，= 0.031）和顺式-7,10,13,16-二十二碳四烯酸（0.494 vs 0.778，< 0.001）均降低。尽管进行了血糖管理，母体、胎盘和胎儿中的脂肪酸谱仍受到GDM的影响，尤其是omega-3和omega-6长链多不饱和脂肪酸。这一发现表明，解决胎儿脂肪酸缺乏可能取决于纠正胎盘功能障碍，而非仅仅增加母体脂肪酸补充，为制定GDM的营养和治疗策略提供了见解。
Abstract
Gestational diabetes mellitus (GDM) affects the transfer of fatty acid (FA) from mother to fetus. However, the specific transport alterations remain unclear. This study investigated FA transport from mother to fetus in GDM. Maternal serum, umbilical cord serum, and placental tissues were collected from 20 healthy (normal group) and 20 GDM pregnancies receiving glycemic management (GDM group). Fifty-one FA were quantified by gas chromatography-mass spectrometry. Placenta/mother and fetus/placenta ratios of FA compositions were compared between groups using Student's t-test or Mann-Whitney U test, as appropriate. The concentrations and compositions of FA profiles were both changed in GDM. The placenta/mother ratios of cis-11,14,17-eicosatrienoic acid (GDM vs normal: 0.648 vs 0.484, = 0.001), cis-5,8,11,14,17-eicosapentaenoic acid (0.449 vs 0.338, = 0.048), cis-13,16-docosadienoic acid (DDA, 1.436 vs 1.187, = 0.047), palmitelaidic acid (2.882 vs 2.272, = 0.023), petroselaidic acid (2.177 vs 1.746, = 0.004) and linoelaidic acid (1.770 vs 1.423, = 0.014) were significantly higher in GDM, while the ratio of trans-10-nonadecenoic acid (0.537 vs 0.799, < 0.001) was lower. The fetus/placenta ratio of total omega-6 long chain polyunsaturated FA (LC PUFA, 0.545 vs 0.590, = 0.002) with DDA (4.031 vs 4.951, = 0.031) and cis-7,10,13,16-docosatetraenoic acid (0.494 vs 0.778, < 0.001) was lower in GDM. FA profiles in mother, placenta, and fetus were affected by GDM despite glycemic management, especially in omega-3 and omega-6 LC PUFAs. This finding indicates that addressing fetal FA deficiency may depend on correcting placental dysfunction rather than solely increasing maternal FA supplementation, offering insights for developing nutritional and therapeutic strategies for GDM.
如何引用
AMA
Wei Long, Fang Guo, Jun Yao, Qinjun Wei, Lizhong Yin, Jiawen Xu, et al. Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.. Annals of medicine. 2026; doi:10.1080/07853890.2026.2653945.
APA
Wei Long, Fang Guo, Jun Yao, Qinjun Wei, Lizhong Yin, Jiawen Xu, et al (2026). Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.. Annals of medicine. https://doi.org/10.1080/07853890.2026.2653945
GB/T 7714
Wei Long, Fang Guo, Jun Yao, Qinjun Wei, Lizhong Yin, Jiawen Xu, et al. Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.[J]. Annals of medicine, 2026 doi:10.1080/07853890.2026.2653945.
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