情节记忆回路中重度抑郁症的神经特征
Neural signatures of major depression across the episodic memory circuitry.
摘要(中文译文)
在重性抑郁障碍（MDD）中，情景记忆受损并与海马功能障碍相关，但其潜在的神经环路仍知之甚少。我们研究了支持情景记忆的环路，并评估了其与MDD相关的解剖连接指纹。解剖连接通过磁共振成像（MRI）弛豫测量衍生的区域体积和髓鞘含量指标进行评估，样本为1339名社区居住成年人（平均年龄61±9岁；女性671名）。为获得情景记忆环路的无偏定义，我们估算了源自海马区域的全脑解剖协方差模式，这些区域在一个独立样本中于功能性MRI情景记忆任务期间显示出与MDD相关的差异性神经活动模式。基于形态学的情景记忆环路涵盖额叶、顶叶和颞叶皮层、杏仁核、苍白球和丘脑（所有|r|>0.106，P<.05），其前海马和后海马区域显示出相似的协方差模式。相反，由髓鞘含量定义的环路显示皮层与皮层下结构之间呈反向协方差模式，但两个海马区域之间趋同。与眶回、苍白球、岛叶，尤其是丘脑核团的连接对终生MDD诊断个体（n=700，平均年龄59±9岁；女性432名）相较于无MDD诊断者（n=639，平均年龄63±10岁；女性239名）具有判别力（所有|Z|>1.96，所有P<.05，双尾）。我们的发现提供了抑郁相关情景记忆功能障碍背后脑环路改变的证据。这些环路的连接改变提示多条通路在抑郁的维持和病因学中发挥作用，并代表治疗干预的潜在靶点。
Abstract
In major depressive disorder (MDD), episodic memory is compromised and linked to hippocampal dysfunction, yet the underlying neural circuitry remains poorly understood. We examined the circuits supporting episodic memory and assessed its MDD-associated anatomical connectivity fingerprints. Anatomical connectivity was assessed using magnetic resonance imaging (MRI) relaxometry-derived indices of regional volume and myelin content from 1339 community-dwelling adults (mean age 61 ± 9 y; 671 females). To obtain an unbiased definition of episodic memory circuits, we estimated whole-brain anatomical covariance patterns originating from hippocampal regions that, in an independent sample, showed differential MDD-related neural activity patterns during a functional MRI episodic memory task. The morphometry-based episodic memory circuit encompassing frontal, parietal and temporal cortex, amygdala, pallidum, and thalamus (all |r| > 0.106, P < .05), showed similar covariance patterns for the anterior and posterior hippocampal regions. Conversely, myelin content-defined circuits showed inverse covariance patterns between cortical and subcortical structures, yet convergent for the two hippocampal regions. Connectivity with the orbital gyri, pallidum, insula, and, in particular, the thalamic nuclei was discriminative (all |Z| > 1.96, all P < .05, two-tailed) for individuals with a lifetime MDD diagnosis (n = 700, mean age 59 ± 9 y; 432 females) compared to those without (n = 639, mean age 63 ± 10 y; 239 females). Our findings provide evidence of altered brain circuits underlying depression-related dysfunctional episodic memory. Altered connectivity in these circuits suggests roles for multiple pathways in the maintenance and aetiology of depression and represents a potential target for therapeutic interventions.
如何引用
AMA
Cristina Ramponi, Lucien Gyger, Kevin Swierkosz-Lenart, Adeliya Latypova, Tobias Bracht, Giulia DiDomenicantonio, et al. Neural signatures of major depression across the episodic memory circuitry.. Journal of affective disorders. 2026; doi:10.1016/j.jad.2026.121820.
APA
Cristina Ramponi, Lucien Gyger, Kevin Swierkosz-Lenart, Adeliya Latypova, Tobias Bracht, Giulia DiDomenicantonio, et al (2026). Neural signatures of major depression across the episodic memory circuitry.. Journal of affective disorders. https://doi.org/10.1016/j.jad.2026.121820
GB/T 7714
Cristina Ramponi, Lucien Gyger, Kevin Swierkosz-Lenart, Adeliya Latypova, Tobias Bracht, Giulia DiDomenicantonio, et al. Neural signatures of major depression across the episodic memory circuitry.[J]. Journal of affective disorders, 2026 doi:10.1016/j.jad.2026.121820.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出