低剂量接触有机磷农药和慢性肾病：来自尿中磷酸二烷基酯生物标志物的见解
Low-dose exposure to organophosphate pesticides and chronic kidney disease: insights from urinary dialkyl phosphate biomarkers.
摘要(中文译文)
有机磷农药（OPP）暴露是一个公共卫生问题，但一般人群中慢性低水平暴露与慢性肾脏病（CKD）之间的关联仍不明确。本研究探讨了美国成年人尿中二烷基磷酸酯（DAP）代谢物与CKD患病率之间的关联。研究分析了来自五个NHANES周期（2003-2008年、2011-2016年）的5751名年龄≥20岁参与者的数据。尿DAP代谢物作为近期OPP或环境DAP暴露的生物标志物。采用调查加权回归模型评估CKD关联。对检测频率充足的代谢物进行了二次混合分析，包括加权分位数和（WQS）、贝叶斯核机器回归（BKMR）和分位数g计算（QGC）。总体而言，18.7%的参与者符合CKD标准。在各模型中，较高浓度的二乙基磷酸酯（DEP）和二乙基硫代磷酸酯（DETP）始终与CKD患病率升高相关。混合分析确定DEP和DETP是总体关联的主要贡献者。这项横断面研究表明，特定DAPs（DEP和DETP）暴露与CKD风险增加之间存在潜在关联，并得到多种统计模型的支持。有必要开展纵向研究以确立因果关系，并对不明原因CKD病例进行OPPs暴露的临床筛查。
Abstract
Organophosphorus pesticide (OPP) exposure is a public health concern, yet the link between chronic low-level exposure and chronic kidney disease (CKD) in the general population remains unclear. This study investigated the association between urinary dialkyl phosphate (DAP) metabolites and CKD prevalence among U.S. adults. Data from 5751 participants aged ≥ 20 years across five NHANES cycles (2003-2008, 2011-2016) were analyzed. Urinary DAP metabolites served as biomarkers of recent OPP or environmental DAP exposure. CKD associations were assessed using survey-weighted regression models. Secondary mixture analyses, including weighted quantile sum (WQS), Bayesian kernel machine regression (BKMR), and quantile g-computation (QGC), were conducted on metabolites with adequate detection frequency. Overall, 18.7% of participants met CKD criteria. Higher concentrations of diethylphosphate (DEP) and diethylthiophosphate (DETP) were consistently associated with increased CKD prevalence across models. Mixture analyses identified DEP and DETP as primary contributors to the overall association. This cross-sectional study indicates a potential link between exposure to specific DAPs (DEP and DETP) and an increased risk of CKD, supported by multiple statistical models. Longitudinal research to establish causality and clinical screening for OPPs exposure in unexplained CKD cases is warranted.
如何引用
AMA
Xiaofen Ma, Xinxin Jiang, Dongyuan He, Qing Qing Duan, Binbin Wu, Xiaohui Xie, et al. Low-dose exposure to organophosphate pesticides and chronic kidney disease: insights from urinary dialkyl phosphate biomarkers.. Clinical and experimental nephrology. 2026; doi:10.1007/s10157-026-02866-1.
APA
Xiaofen Ma, Xinxin Jiang, Dongyuan He, Qing Qing Duan, Binbin Wu, Xiaohui Xie, et al (2026). Low-dose exposure to organophosphate pesticides and chronic kidney disease: insights from urinary dialkyl phosphate biomarkers.. Clinical and experimental nephrology. https://doi.org/10.1007/s10157-026-02866-1
GB/T 7714
Xiaofen Ma, Xinxin Jiang, Dongyuan He, Qing Qing Duan, Binbin Wu, Xiaohui Xie, et al. Low-dose exposure to organophosphate pesticides and chronic kidney disease: insights from urinary dialkyl phosphate biomarkers.[J]. Clinical and experimental nephrology, 2026 doi:10.1007/s10157-026-02866-1.
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