不同强度的体育活动对衰老的影响：一项孟德尔随机化研究
The impact of different intensities of physical activity on aging: A Mendelian randomization study.
摘要(中文译文)
现有观察性研究提供的证据尚不足以确立体力活动与衰老过程之间的因果关系。本研究旨在采用双样本孟德尔随机化方法，确定不同强度的体力活动对生物学衰老的因果效应。从欧洲血统个体的全基因组关联研究中提取体力活动与衰老替代指标的汇总数据，以进行孟德尔随机化分析。采用五种孟德尔随机化分析技术以减少潜在偏倚并确保数据的稳健性，其中以逆方差加权法作为主要输出结果。进行敏感性实验以评估异质性和多效性，从而保证结果的稳健性。孟德尔随机化分析结果表明，基因预测的步行活动与较长的端粒长度相关（β = 0.118；95% CI [0.022-0.215]；P = .01）。此外，剧烈运动与GrimAge之间存在显著的负向因果关联（β = -1.432；95% CI [-2.774至-0.091]；P = .036）。通过进行一系列敏感性分析，进一步验证了这些发现的稳健性。本研究提供的证据支持体力活动与较慢衰老之间存在潜在因果关系。这种关联体现在端粒长度的维持和GrimAge进展的减缓上。因此，鼓励体力活动可作为减缓衰老过程的有效途径。
Abstract
The extant corpus of observational studies has yielded an inadequate body of evidence to establish a causal relationship between physical activity (PA) and the process of aging. This study aimed to determine the causal effects of different intensities of PA on biological aging using a 2-sample Mendelian randomization (MR) approach. Pooled data on PA and aging proxies were extracted from genome-wide association studies on individuals of European ancestry in order to perform MR analysis. Five MR analysis techniques were employed to reduce potential biases and ensure the robustness of the data, with the inverse-variance weighted method serving as the primary output. Sensitivity experiments were conducted to assess heterogeneity and pleiotropy in order to guarantee the results' robustness. The results of the MR analysis demonstrated that genetically predicted walking activity was associated with longer telomere length (β = 0.118; 95% CI [0.022-0.215]; P = .01). Additionally, a significant negative causal relationship was identified between strenuous exercise and GrimAge (β = -1.432; 95% CI [-2.774 to -0.091]; P = .036). The robustness of these findings was further validated through conducting a series of sensitivity analyses. This research offers evidence supports a potential causal relationship between PA and slower aging. This connection is reflected in the preservation of telomere length and the slowing of GrimAge progression. As a result, encouraging PA could serve as an effective approach to mitigate the aging process.
如何引用
AMA
Hongxin Li, Wang Guo, Qiwen Nie, Qiang Tang, Hongyu Li. The impact of different intensities of physical activity on aging: A Mendelian randomization study.. Medicine. 2026; doi:10.1097/MD.0000000000048055.
APA
Hongxin Li, Wang Guo, Qiwen Nie, Qiang Tang, Hongyu Li (2026). The impact of different intensities of physical activity on aging: A Mendelian randomization study.. Medicine. https://doi.org/10.1097/MD.0000000000048055
GB/T 7714
Hongxin Li, Wang Guo, Qiwen Nie, Qiang Tang, Hongyu Li. The impact of different intensities of physical activity on aging: A Mendelian randomization study.[J]. Medicine, 2026 doi:10.1097/MD.0000000000048055.
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