[肌少症与骨质疏松症的相关性]

摘要(中文译文)

肌少症与骨质疏松症是老年人群中常见的两种代谢性疾病。研究发现，二者在发病过程中存在相互促进的相关性。流行病学研究提示，肌少症与骨质疏松症的发病率呈正相关。遗传学研究发现了可同时调控低骨密度与低肌肉量的基因。细胞生物学研究发现，存在同时作用于肌细胞和骨细胞的细胞因子，其含量变化可直接导致肌肉量和骨密度下降。危险因素研究发现，存在机制较为明确的共同危险因素可导致肌少症与骨质疏松症同时发病。然而，证明肌少症与骨质疏松症在发病过程中相互促进的综合高水平证据尚不完善，对其共病机制的研究尚不完善，这阻碍了治疗此类疾病药物的研发。因此，及时诊断其中一种疾病并控制共同危险因素，是防治肌少症与骨质疏松症共病的有效方法。

Abstract

Sarcopenia and osteoporosis are two common metabolic diseases among the elderly population. Studies have found that there was a mutually reinforcing correlation in the process of their onset. Epidemiological research indicated that the incidence rates of sarcopenia and osteoporosis were positively correlated. Genetic studies have discovered genes that could simultaneously control low bone density and low muscle mass. Cell biology research has found that there were cytokines that act on both muscle cells and bone cells, and changes in their content could directly cause a decrease in muscle mass and bone density. Risk factor studies have found that there were common risk factors with a relatively clear mechanism that could cause the simultaneous onset of sarcopenia and osteoporosis. However, comprehensive high-level evidence demonstrating the mutual promotion of sarcopenia and osteoporosis during their onset was not yet complete, and the research on mechanism of their co-occurrence was not yet perfect, which has hindered the development of drugs for treating these diseases. Therefore, timely diagnosis of one of these diseases and control of common risk factors are effective methods for preventing and treating the co-occurrence of sarcopenia and osteoporosis.

如何引用