Acomys cahirinus seurati是利什曼原虫的潜在宿主
{"_":" as a Potential Reservoir Host of .","i":["Acomys cahirinus seurati","Leishmania major"]}
摘要(中文译文)
由（）引起的皮肤利什曼病（CL）是一种由白蛉传播的人兽共患病。鉴定储存宿主对于理解传播机制和指导防控至关重要。虽然（）和（）被认为是北非的储存宿主，但其他啮齿动物的作用仍不明确。我们通过实验评估了来自阿尔及利亚东南部的（）的储存宿主潜力。对动物进行皮内感染，并监测临床症状及对白蛉的传染性。通过定量PCR检测皮肤和内脏组织中寄生虫的持续存在情况。所有动物均出现局限性、自限性病变。16只动物中有7只在感染后10至25周期间将寄生虫传播给（）。寄生虫主要局限于接种部位，有限播散至对侧耳廓和后爪，脾或肝中罕见存在。值得注意的是，部分动物在无可见病变的情况下即具有传染性，表明溃疡形成并非传播所必需。这些发现表明，（）可将（）感染维持长达6个月，并将寄生虫传播给白蛉，符合储存宿主的关键标准。因此，在缺乏经典储存宿主的疫源地中，该物种可能促进CL传播，强调在北非的监测和防控规划中有必要考虑替代啮齿动物宿主。
Abstract
Cutaneous leishmaniasis (CL) caused by is a zoonotic disease transmitted by phlebotomine sand flies. Identification of reservoir hosts is critical for understanding transmission and guiding control. While and are recognized reservoirs in North Africa, the role of other rodents remains unclear. We experimentally assessed the reservoir potential of from southeastern Algeria. Animals were intradermally infected, and clinical signs and infectiousness to sand flies were monitored. Parasite persistence in skin and visceral tissues was measured by quantitative PCR. All animals developed localized, self-limiting lesions. Seven of sixteen individuals transmitted parasites to between 10 and 25 weeks post-infection. Parasites were mostly restricted to the inoculation site, with limited dissemination to contralateral pinnae and hindpaws, and rare presence in spleen or liver. Notably, some animals were infectious without visible lesions, indicating that ulceration is not required for transmission. These findings show that can maintain infection for up to 6 months and transmit parasites to sand flies, fulfilling key criteria of a reservoir host. Thus, this species may contribute to CL transmission in endemic foci lacking classical reservoirs, emphasizing the need to consider alternative rodent hosts in surveillance and control programs in North Africa.
如何引用
AMA
Sergei Karlin, Barbora Bečvářová, Kamal Eddine Benallal, Tomáš Bečvář, Ghania Mezai, Mounir Zaabar, et al. {"_":" as a Potential Reservoir Host of .","i":["Acomys cahirinus seurati","Leishmania major"]}. Pathogens (Basel, Switzerland). 2026; doi:10.3390/pathogens15030268.
APA
Sergei Karlin, Barbora Bečvářová, Kamal Eddine Benallal, Tomáš Bečvář, Ghania Mezai, Mounir Zaabar, et al (2026). {"_":" as a Potential Reservoir Host of .","i":["Acomys cahirinus seurati","Leishmania major"]}. Pathogens (Basel, Switzerland). https://doi.org/10.3390/pathogens15030268
GB/T 7714
Sergei Karlin, Barbora Bečvářová, Kamal Eddine Benallal, Tomáš Bečvář, Ghania Mezai, Mounir Zaabar, et al. {"_":" as a Potential Reservoir Host of .","i":["Acomys cahirinus seurati","Leishmania major"]}[J]. Pathogens (Basel, Switzerland), 2026 doi:10.3390/pathogens15030268.
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