后新冠时代希腊人偏肺病毒的出现和分子流行病学
Emergence and Molecular Epidemiology of Human Metapneumovirus in Greece in the Post-COVID Era.
摘要(中文译文)
近期有报道主张，在新冠疫情后时代，人类偏肺病毒（hMPV）感染在全球范围内重新抬头。鉴于希腊缺乏相关数据，本研究旨在探讨重要基因型变异株的分子流行病学及其可能的重新流行。研究采用全基因组测序及F基因特异性测序，以全面获取希腊 circulating hMPV 毒株的基因型和谱系分布信息。结果显示，与2024年同期相比，2025年月度阳性率在统计学上显著升高，尤其是2月至4月。总体而言，21株被归类为基因型A2.2.2（42.9%），27株为基因型B2（55.1%），仅1株属于基因型B1。大多数完成全基因组测序的A2.2.2毒株的基因携带一段111个核苷酸的重复序列以及基因型特异性的N-糖基化位点模式。最大似然法和时间标尺贝叶斯系统发育分析表明，特定亚谱系在区域层面占据优势，并存在国际传播事件。这种复杂的流行模式，加之hMPV基因所承受的差异性进化压力，主张对hMPV流行病学进行多基因或全基因组测序方法的持续监测。
Abstract
Recent reports have advocated the global resurgence of human metapneumovirus (hMPV) infections in the post-COVID-19 era. Considering the absence of relevant data from Greece, the present study aimed to explore the molecular epidemiology and possible resurgence of significant genotypic variants. Whole genome and F gene-specific sequencing were implemented in order to obtain complete information on the genotype and lineage distribution of circulating hMPV strains in Greece. The results showed a statistically significant increase in monthly positivity rates in 2025, especially from February to April, compared to the respective period in 2024. Overall, 21 strains were classified as genotype A2.2.2 (42.9%) and 27 as genotype B2 (55.1%), whereas only one strain belonged to genotype B1. The gene of most completely sequenced A2.2.2 strains harbored a 111nt duplication sequence and a genotype-specific pattern of -glycosylation sites. Maximum likelihood and time-scaled, Bayesian phylogenetic analyses demonstrated the dominance of specific sub-lineages at the regional level and international transmission events. This complex epidemic pattern in conjunction with the differential evolutionary pressure exerted on the hMPV genes, advocates continuous surveillance of hMPV epidemiology with multiple genes, or complete genome sequencing methodologies.
如何引用
AMA
Nikolaos Siafakas, Korina Papadopoulou, Anastasia Psina, Sotirios Tsiodras, Spyridon Pournaras. Emergence and Molecular Epidemiology of Human Metapneumovirus in Greece in the Post-COVID Era.. International journal of molecular sciences. 2026; doi:10.3390/ijms27062821.
APA
Nikolaos Siafakas, Korina Papadopoulou, Anastasia Psina, Sotirios Tsiodras, Spyridon Pournaras (2026). Emergence and Molecular Epidemiology of Human Metapneumovirus in Greece in the Post-COVID Era.. International journal of molecular sciences. https://doi.org/10.3390/ijms27062821
GB/T 7714
Nikolaos Siafakas, Korina Papadopoulou, Anastasia Psina, Sotirios Tsiodras, Spyridon Pournaras. Emergence and Molecular Epidemiology of Human Metapneumovirus in Greece in the Post-COVID Era.[J]. International journal of molecular sciences, 2026 doi:10.3390/ijms27062821.
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