免疫球蛋白A包被与不同脂肪酸组成的高脂饮食诱导的肠道微生物群改变之间的关联极小
Minimal Association Between Immunoglobulin A Coating and Gut Microbiota Alterations Induced by High-Fat Diets with Distinct Fatty Acid Compositions.
摘要(中文译文)
含不同脂肪酸组成的膳食脂肪的高脂饮食会以脂肪来源依赖的方式改变肠道微生物群组成。免疫球蛋白A和远端肠道中未被吸收的脂质是肠道微生物群的潜在调节因子。然而，它们在介导不同脂肪酸组成的膳食脂肪所诱导的肠道微生物群改变中的作用仍不清楚。本研究旨在探讨这两个因素与脂肪来源依赖性肠道微生物群改变之间的关联。BALB/c小鼠分别被喂食正常饮食、高猪油饮食、高橄榄油饮食或高大豆油饮食，持续27周。收集粪便样本以评估微生物群组成、IgA包被指数——该指数用于量化肠道微生物群被IgA包被的程度——以及粪便脂肪酸浓度。在门水平上，粪便总长链脂肪酸浓度与 Bacillota 的相对丰度呈正相关，与 Bacteroidota 的相对丰度呈负相关。此外，在 Bacillota 中观察到相对丰度与IgA包被指数之间呈正相关趋势，但在 Bacteroidota 中未观察到。在属水平上，12个分类群的相对丰度与粪便长链脂肪酸浓度呈正相关，而6个分类群的相对丰度呈负相关。尽管大多数分类群的相对丰度似乎受到未吸收脂质及其他因素的影响，但只有四个 Bacillota 属表现出相对丰度与IgA包被指数之间的正相关。我们的观察结果表明，在高脂饮食摄入期间，肠道微生物群的IgA包被可能与脂肪来源特异性的肠道微生物群组成改变关联甚微。
Abstract
High-fat diets (HFDs) containing dietary fats with different fatty acid (FA) compositions alter gut microbiota composition in a fat-source-dependent manner. Immunoglobulin A (IgA) and unabsorbed lipids in the distal gut are potential regulators of the gut microbiota. However, their roles in mediating gut microbiota alterations induced by dietary fats with different FA compositions remain unclear. This study aims to examine the associations of these two factors with fat-source-dependent gut microbiota alterations. BALB/c mice were fed a normal diet, a high-lard diet, a high-olive oil diet, or a high-soybean oil diet for 27 weeks. Fecal samples were collected to assess microbiota composition, the IgA coating index (ICI)-which quantifies the extent of IgA coating on gut microbiota-and fecal fatty acid concentrations. At the phylum level, the concentration of fecal total long-chain fatty acids (LCFAs) was positively correlated with the relative abundance (RA) of Bacillota and negatively correlated with that of Bacteroidota. In addition, a trend toward a positive association between the RA and the ICI was observed for Bacillota but not for Bacteroidota. At the genus level, the RAs of 12 taxa were positively correlated with fecal LCFA concentrations, whereas those of 6 taxa were negatively correlated. Although the RAs of most taxa appeared to be influenced by unabsorbed lipids and additional factors, only four Bacillota genera exhibited a positive correlation between the RA and the ICI. Our observations suggest that IgA coating of the gut microbiota may have a minimal association with fat-source-specific alterations in gut microbiota composition during HFD intake.
如何引用
AMA
Mao Teraoka, Naoki Nishino, Tianyang Wang, Kuiyi Chen, Takeshi Tsuruta. Minimal Association Between Immunoglobulin A Coating and Gut Microbiota Alterations Induced by High-Fat Diets with Distinct Fatty Acid Compositions.. International journal of molecular sciences. 2026; doi:10.3390/ijms27062645.
APA
Mao Teraoka, Naoki Nishino, Tianyang Wang, Kuiyi Chen, Takeshi Tsuruta (2026). Minimal Association Between Immunoglobulin A Coating and Gut Microbiota Alterations Induced by High-Fat Diets with Distinct Fatty Acid Compositions.. International journal of molecular sciences. https://doi.org/10.3390/ijms27062645
GB/T 7714
Mao Teraoka, Naoki Nishino, Tianyang Wang, Kuiyi Chen, Takeshi Tsuruta. Minimal Association Between Immunoglobulin A Coating and Gut Microbiota Alterations Induced by High-Fat Diets with Distinct Fatty Acid Compositions.[J]. International journal of molecular sciences, 2026 doi:10.3390/ijms27062645.
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