儿科姑息治疗病房的感染：来自单一中心的临床和微生物学视角
Infections in Pediatric Palliative Care Units: Clinical and Microbiological Perspectives from a Single Center.
摘要(中文译文)
感染与多重耐药（MDR）病原体是儿科姑息治疗（PPC）病房中备受关注的问题，这些病房中的患儿因罹患限制生命的疾病而需接受侵入性操作并长期住院。本研究评估了在PPC病房住院的儿科患者的临床特征、微生物学特征及与MDR感染相关的因素。本回顾性观察研究纳入了2023年6月至2024年1月期间因感染入住我院PPC病房的66名年龄1个月至18岁的儿童。回顾了人口学数据、合并症、器械使用、感染部位及微生物学结果。细菌鉴定和抗菌药物敏感性试验采用Vitek2系统进行，并依据EUCAST标准判读。中位年龄为48个月（IQR 19-106）；63.6%为男性。下呼吸道感染最为常见（68.2%），其次为脓毒症（13.6%）和尿路感染（12.1%）。（36.4%）和（27.3%）占主导地位。MDR菌株占分离株的15.2%。MDR感染与经皮内镜下胃造瘘术或机械通气的使用显著相关（P = 0.033）。住院时间延长和多种合并症倾向于增加MDR风险，但未达到统计学显著性。革兰阴性MDR感染是PPC病房中的重要问题。频繁接触侵入性器械和抗菌药物增加了对耐药病原体的易感性。加强感染预防、优化抗菌药物管理以及监测器械相关感染对于降低发病率、提高儿科姑息治疗质量至关重要。
Abstract
: Infections and multidrug-resistant (MDR) pathogens are concerns in pediatric palliative care (PPC) units, where children with life-limiting conditions undergo invasive procedures and prolonged hospitalization. This study evaluated clinical characteristics, microbiological profiles, and factors associated with MDR infections among pediatric patients hospitalized in a PPC unit. : This retrospective observational study included 66 children aged 1 month to 18 years who were admitted to the PPC unit of our hospital due to infection between June 2023 and January 2024. Demographic data, comorbidities, device use, infection sites, and microbiological results were reviewed. Bacterial identification and antimicrobial susceptibility testing were performed using the Vitek2 system and interpreted according to EUCAST. : The median age was 48 months (IQR 19-106); 63.6% were male. Lower respiratory tract infection was most common (68.2%), followed by sepsis (13.6%) and urinary tract infection (12.1%). (36.4%) and (27.3%) predominated. MDR organisms represented 15.2% of isolates. MDR infections were significantly associated with percutaneous endoscopic gastrostomy or mechanical ventilation use ( = 0.033). Prolonged hospitalization and multiple comorbidities tended to increase the MDR risk but did not reach statistical significance. : Gram-negative MDR infections constitute an important problem in PPC units. Frequent exposure to invasive devices and antibiotics increases susceptibility to resistant pathogens. Reinforcing infection prevention, optimizing antimicrobial stewardship, and monitoring device-related infections are essential to reduce morbidity and improve care quality in pediatric palliative care.
如何引用
AMA
Sefika Aldas, Merve Türkegün Şengül, Berfin Ozgökçe Ozmen, Sanlıay Sahin. Infections in Pediatric Palliative Care Units: Clinical and Microbiological Perspectives from a Single Center.. Antibiotics (Basel, Switzerland). 2026; doi:10.3390/antibiotics15030261.
APA
Sefika Aldas, Merve Türkegün Şengül, Berfin Ozgökçe Ozmen, Sanlıay Sahin (2026). Infections in Pediatric Palliative Care Units: Clinical and Microbiological Perspectives from a Single Center.. Antibiotics (Basel, Switzerland). https://doi.org/10.3390/antibiotics15030261
GB/T 7714
Sefika Aldas, Merve Türkegün Şengül, Berfin Ozgökçe Ozmen, Sanlıay Sahin. Infections in Pediatric Palliative Care Units: Clinical and Microbiological Perspectives from a Single Center.[J]. Antibiotics (Basel, Switzerland), 2026 doi:10.3390/antibiotics15030261.
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