中国广州地区甲状腺功能减退症控制现状：横断面调查
Current status of hypothyroidism control in Guangzhou area, China: a cross-sectional survey.
摘要(中文译文)
背景：甲状腺功能减退症是一种严重危害工作与生活的疾病。目前，中国缺乏大规模的治疗控制状况调查。本研究旨在结合广州地区大样本甲状腺功能减退症患者，分析甲状腺功能减退症的控制率。方法：在广州市六家三级甲等医院开展横断面调查。对随机抽样的甲状腺功能减退症门诊患者（n=1516）进行现场问卷调查，以收集横断面数据。对收集的数据进行分析，总结广州地区甲状腺功能减退症的控制现状、甲状腺功能减退症病因构成、并发症及其与甲状腺功能减退症控制率的相关性。结果：甲状腺功能减退症患者的总体控制率（以TSH水平<4 mU/L为标准）为59.4%（男性49.2%，女性61.2%）。TSH控制率与性别和教育程度之间存在显著相关性。此外，年龄<35岁者以及妊娠期甲状腺功能减退症孕妇妊娠中期的治疗后TSH控制率较高。TSH控制率与肝功能异常、月经紊乱、痛经和睡眠障碍密切相关。最后，甲状腺手术史、甲状腺手术类型以及桥本甲状腺炎的存在与TSH控制率相关。结论：广州地区甲状腺功能减退症患者的控制率相对较低。具有与甲状腺功能减退症控制不佳密切相关的临床特征的甲状腺功能减退症患者应受到特别关注。临床试验注册号：不适用。
Abstract
BACKGROUND: Hypothyroidism is a significantly harmful condition that severely affects work and daily life. Currently, there is a lack of large-scale investigations into the treatment control status in China. This study aimed to combine a large sample of patients with hypothyroidism in the Guangzhou area to analyze hypothyroidism control rates. METHODS: A cross-sectional survey was conducted at six tertiary A-grade hospitals in Guangzhou city. On-site questionnaire surveys were administered to randomly sampled outpatients with hypothyroidism (n = 1516) to collect cross-sectional data. The collected data were analyzed to summarize the current status of hypothyroidism control, the composition of hypothyroidism etiology, complications, and their correlation with hypothyroidism control rates in Guangzhou. RESULTS: The overall control rate of patients with hypothyroidism (with TSH level < 4 mU/L as the standard) was 59.4% (49.2% in males and 61.2% in females). There was a significant correlation between TSH control rate and sex and education. In addition, the TSH control rate after treatment was higher in those aged < 35 years and during the mid-term of pregnancy in pregnant women with hypothyroidism. The control rate of TSH was closely associated with abnormal liver function, menstrual disorders, dysmenorrhea, and sleep disorders. Finally, a history of thyroid surgery, type of thyroid surgery, and presence of Hashimoto’s thyroiditis were correlated with the control rate of TSH. CONCLUSION: The control rate in patients with hypothyroidism was relatively low in Guangzhou area. Patients with hypothyroidism and clinical characteristics closely associated with poor hypothyroidism control should receive special attention. CLINICAL TRIAL NUMBER: Not applicable.
如何引用
AMA
Bo Chen, Shaobo Wang, Yali Huang, Deqing Liu, Runjie Chen, Hua Zhang, et al. Current status of hypothyroidism control in Guangzhou area, China: a cross-sectional survey.. BMC endocrine disorders. 2026; doi:10.1186/s12902-026-02214-0.
APA
Bo Chen, Shaobo Wang, Yali Huang, Deqing Liu, Runjie Chen, Hua Zhang, et al (2026). Current status of hypothyroidism control in Guangzhou area, China: a cross-sectional survey.. BMC endocrine disorders. https://doi.org/10.1186/s12902-026-02214-0
GB/T 7714
Bo Chen, Shaobo Wang, Yali Huang, Deqing Liu, Runjie Chen, Hua Zhang, et al. Current status of hypothyroidism control in Guangzhou area, China: a cross-sectional survey.[J]. BMC endocrine disorders, 2026 doi:10.1186/s12902-026-02214-0.
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