育龄女性不孕不育与体重相关指标的关系：NHANES 2013-2016横断面研究

摘要(中文译文)

为进一步评估肥胖与不孕症之间的关系，我们采用了一种新型人体测量指标，专门用于评估身体形态指数（ABSI）与育龄女性不孕症之间的关系。此外，我们还考察了ABSI与内脏肥胖指数（VAI）与不孕症的相关性。基于2013年至2016年美国国家健康与营养调查（NHANES）数据，共纳入1989名育龄女性参与者。ABSI的计算方法为腰围除以体重指数（BMI）与身高的乘积。VAI采用以下公式计算：腰围/（36.58＋（1.89×BMI））×（甘油三酯/0.81）×（1.52/高密度脂蛋白胆固醇）。不孕或生育状态通过生殖健康问卷对育龄女性参与者进行访谈来定义。采用加权多因素logistic回归分析探讨ABSI与不孕症之间的独立关系。同时进行了平滑曲线拟合、亚组分析和交互作用检验。在1989名参与者中，183名（9.2%）女性被归类为不孕。logistic回归模型显示，ABSI与不孕症呈正相关，即使在调整所有混杂因素后仍具有统计学意义（OR＝1.31，95% CI：1.07-1.60，＝0.0098）。这种关联在所有亚组中均保持一致（年龄、种族、吸烟、饮酒、高血压、糖尿病以及过去12个月月经规律性），（所有交互作用＞0.05）。平滑曲线拟合结果显示，ABSI与不孕症之间存在线性正相关关系。体重指数与不孕症之间存在统计学显著的正相关。随着身体形态指数的升高，育龄女性不孕的风险更大。

Abstract

To further assess the relationship between obesity and infertility, we employed a novel anthropometric index, specifically designed to assess the relationship between a body shape index (ABSI) and infertility in women of childbearing age. Furthermore, we examined the correlation between ABSI and visceral obesity index (VAI) in relation to infertility. A total of 1989 female participants of childbearing age were included, based on National Health and Nutrition Examination Survey (NHANES) data from 2013 to 2016. The ABSI is calculated by dividing waist circumference by body mass index (BMI) * height. VAI was calculated using the following formula: waist circumference/(36.58 + (1.89*BMI)) x (triglycerides/0.81) × (1.52/HDL cholesterol). Infertility or fertility status was defined by interviewing female participants of childbearing age through a reproductive health questionnaire. Weighted multifactorial logistic regression analysis was used to explore the independent relationship between ABSI and infertility. Smoothed curve fitting, subgroup analyses and interaction tests were also performed. Among the 1989 participants, 183 (9.2%) women were categorized as infertile. Logistic regression modeling showed that ABSI was positively associated with infertility and remained significant even after adjusting for all confounders(OR = 1.31, 95% CI: 1.07-1.60, = 0.0098). This association was consistent across all subgroups (age, race, smoking, alcohol consumption, hypertension, diabetes mellitus, and the regularity of menstruation over the previous 12 months), ( > 0.05 for all interactions). The results of the smooth curve fitting demonstrated a linear, positive association between ABSI and infertility. There is a statistically significant positive correlation between body mass index and infertility. As a body shape index rises, women of childbearing age are at greater risk of infertility.

如何引用

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 的其他文献

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