S100A8/A9：程序性细胞死亡网络和疾病进展中的关键调节因子
S100A8/A9: key regulatory factors in programmed cell death networks and disease progression.
摘要(中文译文)
程序性细胞死亡（PCD）是多细胞生物中一种关键的终末代谢途径，与多种生物学过程密切相关。钙卫蛋白（S100A8/A9）作为S100蛋白家族成员，在调控多种形式的PCD中发挥重要作用。作为一种损伤相关分子模式（DAMP），S100A8/A9与Toll样受体4（TLR4）和晚期糖基化终产物受体（RAGE）等受体结合，激活核因子κB（NF-κB）、丝裂原活化蛋白激酶（MAPK）、活性氧（ROS）以及磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）等下游通路。通过这些通路，S100A8/A9介导多种细胞命运过程，包括细胞凋亡、自噬、焦亡、铁死亡、坏死性凋亡和PANoptosis。靶向S100A8/A9的干预策略在炎症性疾病和肿瘤模型中已展现出潜在的治疗价值。本文综述了S100A8/A9在PCD调控中的分子机制及研究进展，探讨其在多种细胞死亡模式中的协同作用，并讨论其作为治疗靶点的应用前景，为相关疾病的机制分析和精准干预提供思路与理论基础。
Abstract
Programmed cell death (PCD) is a critical terminal metabolic pathway in multicellular organisms that is closely associated with various biological processes. Calprotectin (S100A8/A9), a member of the S100 protein family, plays a crucial role in regulating multiple forms of PCD. As a damage-associated molecular pattern (DAMP), S100A8/A9 binds to receptors including Toll-like receptor 4 (TLR4) and receptor for advanced glycation end products (RAGE), activating downstream pathways such as nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK), reactive oxygen species (ROS), and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). Through these pathways, S100A8/A9 mediates various cellular fate processes including apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis, and PANoptosis. Intervention strategies targeting S100A8/A9 have demonstrated potential therapeutic value in inflammatory diseases and tumor models. This review summarizes the molecular mechanisms and research progress of S100A8/A9 in PCD regulation, explores its coordinated role in various cell death patterns, and discusses its application prospects as a therapeutic target, providing insights and a theoretical foundation for mechanism analysis and precise intervention in related diseases.
如何引用
AMA
Jiewei Chen, Jingpu Zheng, Yizhen Li, Xiaochuan Liu, Jinsi Wang, Junjie Jiang, et al. S100A8/A9: key regulatory factors in programmed cell death networks and disease progression.. Biochemical pharmacology. 2026; doi:10.1016/j.bcp.2026.117914.
APA
Jiewei Chen, Jingpu Zheng, Yizhen Li, Xiaochuan Liu, Jinsi Wang, Junjie Jiang, et al (2026). S100A8/A9: key regulatory factors in programmed cell death networks and disease progression.. Biochemical pharmacology. https://doi.org/10.1016/j.bcp.2026.117914
GB/T 7714
Jiewei Chen, Jingpu Zheng, Yizhen Li, Xiaochuan Liu, Jinsi Wang, Junjie Jiang, et al. S100A8/A9: key regulatory factors in programmed cell death networks and disease progression.[J]. Biochemical pharmacology, 2026 doi:10.1016/j.bcp.2026.117914.
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