植物来源的类外泌体纳米囊泡在治疗溃疡性结肠炎中的生物发生、制备、表征、治疗机制和安全性评估
Biogenesis, preparation, characterization, therapeutic mechanisms and safety evaluation of plant-derived exosome-like nanovesicles in the treatment of ulcerative colitis.
摘要(中文译文)
溃疡性结肠炎因其复杂的病因和现有疗法的局限性，仍是一种具有挑战性的临床疾病。植物来源的外泌体样纳米囊泡（PDELNs）代表了一类新型天然纳米治疗药物，在溃疡性结肠炎治疗方面具有巨大潜力。这些纳米颗粒具有高生物相容性、穿越生物屏障的能力，并携带丰富的生物活性分子货物。本综述综合了过去十年PDELN研究的进展，重点关注已建立的制备方法及其多靶点治疗机制。目前抗结肠炎PDELNs的分离方法主要是各类离心法，包括超速离心、差速离心、密度梯度离心及其组合。在治疗方面，PDELNs通过强效抗炎作用、肠道菌群重塑和免疫应答调节来缓解结肠炎。这些效应归因于植物微小RNA、代谢物和脂质等关键生物活性成分。值得注意的是，PDELNs表现出优异的安全性特征，未报告毒性。其天然来源、多靶点机制和良好的生物安全性使PDELNs成为有前景的下一代抗结肠炎治疗候选药物，有效 bridging 了传统植物疗法与现代纳米医学。
Abstract
Ulcerative colitis remains a challenging clinical condition due to its complex etiology and the limitations of current therapies. Plant-derived exosome-like nanovesicles (PDELNs) represent a new class of natural nanotherapeutics with significant potential for ulcerative colitis treatment. These nanoparticles exhibit high biocompatibility, the ability to cross biological barriers, and carry a rich cargo of bioactive molecules. This review synthesizes progress in PDELN research over the past decade, focusing on established preparation methods and their multi-targeted therapeutic mechanisms. The current isolation methods of the anti-colitis PDELNs are mainly various types of centrifugation, including ultracentrifugation, differential centrifugation, density gradient centrifugation and their combination. Therapeutically, PDELNs alleviate colitis through potent anti-inflammatory effects, gut microbiota remodeling, and immune response regulation. These effects are attributed to key bioactive components such as plant microRNAs, metabolites, and lipids. Notably, PDELNs demonstrate an excellent safety profile without reported toxicity. Their natural origin, multi-targeted mechanisms, and favorable biosafety profile make PDELNs a promising next-generation therapeutic candidate against colitis, effectively bridging traditional phytotherapy and modern nanomedicine.
如何引用
AMA
Cailan Li, Luyou Zhao, Xuefei Wang, Jingjing Wu, Haohui Chen, Qiang Lu. Biogenesis, preparation, characterization, therapeutic mechanisms and safety evaluation of plant-derived exosome-like nanovesicles in the treatment of ulcerative colitis.. Journal of nanobiotechnology. 2026; doi:10.1186/s12951-026-04209-4.
APA
Cailan Li, Luyou Zhao, Xuefei Wang, Jingjing Wu, Haohui Chen, Qiang Lu (2026). Biogenesis, preparation, characterization, therapeutic mechanisms and safety evaluation of plant-derived exosome-like nanovesicles in the treatment of ulcerative colitis.. Journal of nanobiotechnology. https://doi.org/10.1186/s12951-026-04209-4
GB/T 7714
Cailan Li, Luyou Zhao, Xuefei Wang, Jingjing Wu, Haohui Chen, Qiang Lu. Biogenesis, preparation, characterization, therapeutic mechanisms and safety evaluation of plant-derived exosome-like nanovesicles in the treatment of ulcerative colitis.[J]. Journal of nanobiotechnology, 2026 doi:10.1186/s12951-026-04209-4.
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