CD8+T细胞在炎症性肠病中的作用和异质性：单细胞转录组学见解的叙述性综述（综述）
{"_":"The roles and heterogeneity of CD8 T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review).","sup":["+"]}
摘要(中文译文)
本综述利用单细胞转录组学探讨了CD8 T细胞在炎症性肠病（IBD）中的作用及特征，揭示了其关键功能和显著的异质性。在IBD中，CD8 T细胞表现出明显的表型和功能多样性，不同亚群具有独特的信号通路激活谱，并与不同的临床结局相关。此外，IBD中的CD8 T细胞亚群参与涉及免疫细胞和非免疫细胞的复杂串扰网络，调节炎症反应和组织稳态。本综述综合了CD8 T细胞在IBD中行为的动态复杂性，并指出了通过靶向调节特定T细胞亚群及其在结肠微环境中相互作用的潜在治疗机会。
Abstract
The present review investigates the role and characteristics of CD8 T cells in inflammatory bowel disease (IBD) using single‑cell transcriptomics, revealing their pivotal functions and remarkable heterogeneity. In IBD, CD8 T cells exhibit marked phenotypic and functional diversity, with distinct subpopulations exhibiting unique signaling pathway activation profiles that associate with varying clinical outcomes. Furthermore, CD8 T cell subsets in IBD participate in complex crosstalk networks involving immune and non‑immune cells, modulating inflammatory responses and tissue homeostasis. The present review synthesizes the dynamic complexity of CD8 T cell behavior in IBD and identifies promising therapeutic opportunities through targeted modulation of specific T cell subsets and their interactions within the colonic microenvironment.
如何引用
AMA
Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, et al. {"_":"The roles and heterogeneity of CD8 T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review).","sup":["+"]}. International journal of molecular medicine. 2026; doi:10.3892/ijmm.2026.5801.
APA
Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, et al (2026). {"_":"The roles and heterogeneity of CD8 T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review).","sup":["+"]}. International journal of molecular medicine. https://doi.org/10.3892/ijmm.2026.5801
GB/T 7714
Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, et al. {"_":"The roles and heterogeneity of CD8 T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review).","sup":["+"]}[J]. International journal of molecular medicine, 2026 doi:10.3892/ijmm.2026.5801.
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