终末期肾病中的带状角膜病变和结膜钙化：流行病学、病理生理学和临床管理
Band keratopathy and conjunctival calcification in end-stage kidney disease: epidemiology, pathophysiology and clinical management.
摘要(中文译文)
结膜和角膜钙化，尤其是其严重表现形式——带状角膜病变，是终末期肾病（ESKD）中一种常见却常被忽视的转移性钙化。本综述整合了关于尿毒症性眼部钙化的流行病学、病理生理学及多学科管理的最新证据。其发病机制以“二次打击”模型进行阐释：全身性“第一次打击”涉及慢性肾脏病-矿物质和骨异常的特异性内环境，由高磷血症、钙负荷、继发性甲状旁腺功能亢进以及钙化抑制剂（如胎球蛋白-A和Klotho）的关键性缺乏所驱动。“第二次打击”则包括眼部局部触发因素，如泪膜不稳定、炎症和局部碱中毒，这些因素促使矿物质在过饱和环境中沉积。
Abstract
Conjunctival and corneal calcification, particularly its severe manifestation, band keratopathy, represents a prevalent yet frequently overlooked form of metastatic calcification in end-stage kidney disease (ESKD). This review integrates current evidence on the epidemiology, pathophysiology and interdisciplinary management of uraemic ocular calcification. The pathogenesis is conceptualized through a 'two-hit' model: the systemic 'first hit' involves the specific milieu of chronic kidney disease-mineral and bone disorder driven by hyperphosphataemia, calcium load, secondary hyperparathyroidism and a critical deficiency in calcification inhibitors such as fetuin-A and Klotho. The 'second hit' comprises local ocular triggers, including tear film instability, inflammation and localized alkalosis, which precipitate mineral deposition in the supersaturated environment.
如何引用
AMA
Nanmei Liu, Ruizhen Ren, Haolin Gou, Maoting Li, Naiying Lan, Fanzhou Zeng, et al. Band keratopathy and conjunctival calcification in end-stage kidney disease: epidemiology, pathophysiology and clinical management.. Clinical kidney journal. 2026; doi:10.1093/ckj/sfag039.
APA
Nanmei Liu, Ruizhen Ren, Haolin Gou, Maoting Li, Naiying Lan, Fanzhou Zeng, et al (2026). Band keratopathy and conjunctival calcification in end-stage kidney disease: epidemiology, pathophysiology and clinical management.. Clinical kidney journal. https://doi.org/10.1093/ckj/sfag039
GB/T 7714
Nanmei Liu, Ruizhen Ren, Haolin Gou, Maoting Li, Naiying Lan, Fanzhou Zeng, et al. Band keratopathy and conjunctival calcification in end-stage kidney disease: epidemiology, pathophysiology and clinical management.[J]. Clinical kidney journal, 2026 doi:10.1093/ckj/sfag039.
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