核心岩藻糖：炎症信号通路中的分子靶点与功能

摘要(中文译文)

糖基化是蛋白质翻译后的关键修饰。细胞表面蛋白（包括受体、转运蛋白和细胞粘附分子）的正常功能和表达取决于糖基化。在各种形式的糖基化中，应用于N-聚糖的核心岩藻糖表现出独特的特征，并在许多生物过程中发挥着重要作用。在这里，我们专注于核心岩藻糖的分子靶点，并回顾了它们在炎症信号通路和免疫系统中的作用。细胞因子受体和toll样受体是核心岩藻糖基化的重要靶点。此外，免疫球蛋白G（IgG）的核心岩藻糖基化在调节抗体依赖性细胞毒性（ADCC）中起着重要作用。包括我们在内的最新研究也表明，IgG的核心岩藻糖水平可以作为监测个体炎症状态的有价值的生物标志物。单糖岩藻糖的调节对靶分子来说是一个小事件，但核心岩藻糖对炎症有显著影响。

Abstract

Glycosylation is a critical post-translational modification of proteins. The proper function and expression of cell-surface proteins-including receptors, transporters, and cell adhesion molecules-depends on glycosylation. Among the various forms of glycosylation, core fucose applied to N-glycans exhibits distinctive characteristics and plays a significant role in numerous biological processes. Here, we focus on the molecular targets of core fucose and review their functions involved in inflammatory signaling pathways and immune systems. Cytokine receptors and toll-like receptors are important targets of core fucosylation. Additionally, core fucosylation of immunoglobulin G (IgG) plays a significant role in regulating antibody-dependent cellular cytotoxicity (ADCC). Recent studies-including ours-also indicate that the level of core fucose of IgG could serve as a valuable biomarker for monitoring inflammatory status in individuals. Modulation with monosaccharide fucose is a small event for the target molecules, but core fucose exerts a significant impact on inflammation.

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