用于癌症细胞成像和PDT/PTT组合应用的Aza-BDIPY-衍生荧光探针
Aza-BODIPY-Derived Fluorescent Probe for Cancer Cell Imaging and Combined PDT/PTT Applications.
摘要(中文译文)
全球健康形势继续受到癌症的挑战，促使正在进行的旨在开发侵袭性更小、更有效的治疗方法的调查。光动力（PDT）和光热（PTT）治疗因其在抑制肿瘤的同时最大限度地减少对周围健康组织的影响而受到重视。这些方法与荧光分子成像（FMI）的结合，因其在癌症早期检测中的巨大潜力而被公认，提出了一种令人信服的无创治疗策略。近红外（NIR）荧光染料，包括花青染料和硼-二吡咯并噻吩（BODIPY）衍生物，以及氮杂-BODIPY衍生物，代表了癌症FMI和光疗中使用的一些最有效的有机小分子。它们强大的组织穿透力、最小的光散射和减少的自发荧光使这些化合物非常适合生物应用。Aza BODIPY是BODIPY有机硼家族的衍生物，以其卓越的光谱特性而闻名，其特征是红移吸收和提高的摩尔消光系数，可增强成像和治疗效果。本研究探讨了aza-BODIPY的潜在修饰，旨在提高其在光疗和癌症检测中的有效性，从而扩大其作为有效癌症治疗策略的多功能工具的应用。
Abstract
The global health landscape continues to be challenged by cancer, prompting ongoing investigations aimed at developing treatments that are both less invasive and more effective. Photodynamic (PDT) and photothermal (PTT) treatments have gained prominence due to their efficacy in inhibiting tumors while minimizing impact on surrounding healthy tissues. The integration of these methodologies with fluorescent molecular imaging (FMI), recognized for its significant potential in early cancer detection, presents a compelling noninvasive treatment strategy. Near-infrared (NIR) fluorescent dyes, including cyanine dyes and boron-dipyrromethene (BODIPY) derivatives, along with aza-BODIPY derivatives, represent some of the most efficient organic small molecules employed in cancer FMI and phototherapy. Their robust tissue penetration, minimal light scattering, and reduced autofluorescence make these compounds highly suitable for biological applications. Aza-BODIPY, a derivative from the organoboron family of BODIPY, is notable for its exceptional spectral properties, featuring red-shifted absorption and elevated molar extinction coefficients that enhance both imaging and therapeutic outcomes. This study examines potential modifications to aza-BODIPY aimed at enhancing its effectiveness in phototherapy and cancer detection, thereby expanding its application as a versatile tool for effective cancer treatment strategies.
如何引用
AMA
Tavish Sharma, Tanya Gupta, Uma Narang. Aza-BODIPY-Derived Fluorescent Probe for Cancer Cell Imaging and Combined PDT/PTT Applications.. Chemistry & biodiversity. 2026; doi:10.1002/cbdv.202503508.
APA
Tavish Sharma, Tanya Gupta, Uma Narang (2026). Aza-BODIPY-Derived Fluorescent Probe for Cancer Cell Imaging and Combined PDT/PTT Applications.. Chemistry & biodiversity. https://doi.org/10.1002/cbdv.202503508
GB/T 7714
Tavish Sharma, Tanya Gupta, Uma Narang. Aza-BODIPY-Derived Fluorescent Probe for Cancer Cell Imaging and Combined PDT/PTT Applications.[J]. Chemistry & biodiversity, 2026 doi:10.1002/cbdv.202503508.
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