负载有以下物质的开放多孔微环境调节微球Curcumin@BSANPs/BMSCs用于糖尿病伤口治疗
Open Porous Microenvironment-regulatory Microspheres Loaded with Curcumin@BSA NPs/BMSCs for Diabetic Wound Treatment.
摘要(中文译文)
糖尿病患者的伤口愈合过程复杂，并受到以慢性炎症和血糖升高为特征的紊乱伤口微环境的显著阻碍。干细胞疗法与药物治疗的结合被认为是未来一种有前景的应用。然而，干细胞有限的增殖能力和药物可利用性不足为实现最佳治疗效果带来了重大挑战。在本研究中，通过气体辅助挥发微乳液技术设计并合成了开放多孔的聚乳酸-羟基乙酸共聚物（PLGA）微球。这些微球包封姜黄素并允许其缓慢释放，从而增强伤口修复。微球中的大孔为骨髓间充质干细胞（BMSCs）提供了充足的支撑，使其能够在35天内持续释放药物。姜黄素的持续释放促进了干细胞增殖并维持了干细胞活性。此外，它还有助于重塑伤口免疫微环境。另外，该微球可激活细胞中的线粒体自噬，有效减轻伤口炎症。姜黄素与干细胞的联合作用有助于损伤部位血管再生和胶原网络恢复活力，从而改善伤口愈合能力。因此，将药物与干细胞及微球相结合在糖尿病伤口治疗方面具有巨大潜力。
Abstract
The process of healing wounds in diabetic patients is intricate and is notably obstructed by a disordered wound microenvironment, characterized by chronic inflammation and elevated blood glucose. The combination of stem cell therapy and drug treatment is seen as a promising application in future. However, the limited proliferative capacity of stem cells and inadequate drug availability present significant challenges for achieving optimal therapeutic outcomes. In this study, open porous poly (lactic‒coglycolic acid) (PLGA) microspheres were designed and synthesized via gas-assisted volatilization microemulsion technology. These microspheres encapsulate curcumin and allow its slow release, thereby enhancing wound repair. The large pores in the microspheres provide ample support for bone marrow stem cells (BMSCs), enabling continuous drug release over a period of 35 days. The sustained release of curcumin promoted stem cell proliferation and maintained stem cell activity. Additionally, it facilitates remodeling of the wound immune microenvironment. Additionally, the microspheres can activate mitochondrial autophagy in cells, effectively alleviating wound inflammation. The combined actions of curcumin and stem cells aid in regenerating blood vessels and revitalizing the collagen network where the injury occurred, thus improving wound healing capabilities. Consequently, integrating drugs with stem cells and microspheres holds significant potential for diabetic wound treatment.
如何引用
AMA
Zhe Liu, Qinzhou Zheng, Dong Zhou, Anqi Lin, Lan Xiao, Haifeng Liu, et al. Open Porous Microenvironment-regulatory Microspheres Loaded with Curcumin@BSA NPs/BMSCs for Diabetic Wound Treatment.. Theranostics. 2026; doi:10.7150/thno.120285.
APA
Zhe Liu, Qinzhou Zheng, Dong Zhou, Anqi Lin, Lan Xiao, Haifeng Liu, et al (2026). Open Porous Microenvironment-regulatory Microspheres Loaded with Curcumin@BSA NPs/BMSCs for Diabetic Wound Treatment.. Theranostics. https://doi.org/10.7150/thno.120285
GB/T 7714
Zhe Liu, Qinzhou Zheng, Dong Zhou, Anqi Lin, Lan Xiao, Haifeng Liu, et al. Open Porous Microenvironment-regulatory Microspheres Loaded with Curcumin@BSA NPs/BMSCs for Diabetic Wound Treatment.[J]. Theranostics, 2026 doi:10.7150/thno.120285.
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