奥氮平血栓栓塞事件：整合荟萃分析和FAERS数据库的系统综述
Thromboembolic events with olanzapine: a systematic review integrating meta-analysis and FAERS database.
摘要(中文译文)
奥氮平是一种用于治疗精神分裂症和躁狂发作的非典型抗精神病药。其潜在的血栓栓塞风险已有报道，但证据仍存在争议。本研究旨在全面评估奥氮平与肺栓塞（PE）及静脉血栓栓塞（VTE）之间的关联。本研究结合荟萃分析与FDA不良事件报告系统（FAERS）数据库的信号挖掘，评估奥氮平与肺栓塞（PE）及静脉血栓栓塞（VTE）之间的关联。从FAERS数据库中55,905份奥氮平相关不良事件报告中，共识别出1,233个显著信号，包括药品说明书中未完整记载的严重不良事件，如肺栓塞和静脉栓塞。对八项研究的荟萃分析显示，使用奥氮平显著增加了VTE和肺栓塞的风险（OR = 2.07，95% CI：1.37-3.14，= 0.0006）。这些发现提示奥氮平与血栓栓塞事件风险增加相关；因此，有必要加强临床监测并进一步研究其安全性。https://www.crd.york.ac.uk/prospero/，标识号CRD420251003254。
Abstract
Olanzapine is an atypical antipsychotic used to treat schizophrenia and manic episodes. Its potential thromboembolic risk has been reported, but the evidence remains controversial. This study aimed to comprehensively evaluate the association between olanzapine and pulmonary embolism (PE) and venous thromboembolism (VTE). This study combined meta-analysis and signal mining from the FDA Adverse Event Reporting System (FAERS) database to assess the association between olanzapine and pulmonary embolism (PE) and venous thromboembolism (VTE). From 55,905 olanzapine-related adverse event reports in the Faers database, 1,233 significant signals were identified, including serious adverse events not fully documented on the drug label, such as pulmonary embolism and venous embolism. A meta-analysis of eight studies showed that olanzapine use significantly increased the risk of VTE and pulmonary embolism (OR = 2.07, 95% CI: 1.37-3.14, = 0.0006). These findings suggest that olanzapine is associated with an increased risk of thromboembolic events; therefore, enhanced clinical surveillance and further investigation into its safety are necessary. https://www.crd.york.ac.uk/prospero/, identifier CRD420251003254.
如何引用
AMA
XueSong Zhang, SiMan Sun, XiaoYu Fan, ShuShu Guo, WanFang Li, Chuan Wang, et al. Thromboembolic events with olanzapine: a systematic review integrating meta-analysis and FAERS database.. Frontiers in cardiovascular medicine. 2026; doi:10.3389/fcvm.2026.1710507.
APA
XueSong Zhang, SiMan Sun, XiaoYu Fan, ShuShu Guo, WanFang Li, Chuan Wang, et al (2026). Thromboembolic events with olanzapine: a systematic review integrating meta-analysis and FAERS database.. Frontiers in cardiovascular medicine. https://doi.org/10.3389/fcvm.2026.1710507
GB/T 7714
XueSong Zhang, SiMan Sun, XiaoYu Fan, ShuShu Guo, WanFang Li, Chuan Wang, et al. Thromboembolic events with olanzapine: a systematic review integrating meta-analysis and FAERS database.[J]. Frontiers in cardiovascular medicine, 2026 doi:10.3389/fcvm.2026.1710507.
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