二甲双胍在胃肠道癌症和炎症性肠病中的作用：揭示其机制和治疗应用
Metformin in gastrointestinal cancers and inflammatory bowel disease: Unraveling its mechanisms and therapeutic applications.
摘要(中文译文)
胃肠道疾病已成为全球关注的健康问题，具有高发病率和患病率。考虑到大量胃肠道肿瘤患者即使经过手术干预或新辅助化疗后仍面临肿瘤复发或远处转移，因此迫切需要寻找新的治疗药物。二甲双胍最初来源于天然草本植物，已被发现对多种疾病有益，不仅包括2型糖尿病、心血管疾病、肝肾疾病和年龄相关疾病，还包括不同类型的癌症。本文全面综述了二甲双胍在胃肠道肿瘤（包括结直肠癌、食管癌和胃癌）以及炎症性肠病中的作用及其潜在机制。通过整合最新研究成果，我们系统阐述了二甲双胍如何通过AMPK/mTOR通路对胃肠道疾病发挥治疗作用以及联合治疗的效果。本综述可能为开发针对胃肠道恶性肿瘤及相关疾病的治疗策略提供新的见解。
Abstract
Gastrointestinal diseases have become a global health concern with high incidence and prevalence. Considering that a great many patients with gastrointestinal cancers still suffer from tumor recurrence or distant metastasis even after surgical intervention or neoadjuvant chemotherapy, it is urgently needed to identify new therapeutic drugs. Metformin, originally derived from natural herbs, has been found to be beneficial for many diseases, including not only type 2 diabetes mellitus, cardiovascular disease, liver and kidney disease, and age-related diseases but also different types of cancers. Herein, we comprehensively review the roles and the underlying mechanisms of metformin in gastrointestinal cancers including colorectal, esophageal, and gastric cancers and also inflammatory bowel disease. By integrating the latest research findings, we systematically elaborate on how metformin exerts therapeutic effects on gastrointestinal diseases through the AMPK/mTOR pathway and the effects of combination therapies. This review may offer novel insights for developing therapeutic strategies against gastrointestinal malignancies and related diseases.
如何引用
AMA
Yanxi Li, Xingqi Guo, Xinxin Dong, Tong Xia, Siping Ma, Zhexian Liu. Metformin in gastrointestinal cancers and inflammatory bowel disease: Unraveling its mechanisms and therapeutic applications.. iScience. 2026; doi:10.1016/j.isci.2026.114877.
APA
Yanxi Li, Xingqi Guo, Xinxin Dong, Tong Xia, Siping Ma, Zhexian Liu (2026). Metformin in gastrointestinal cancers and inflammatory bowel disease: Unraveling its mechanisms and therapeutic applications.. iScience. https://doi.org/10.1016/j.isci.2026.114877
GB/T 7714
Yanxi Li, Xingqi Guo, Xinxin Dong, Tong Xia, Siping Ma, Zhexian Liu. Metformin in gastrointestinal cancers and inflammatory bowel disease: Unraveling its mechanisms and therapeutic applications.[J]. iScience, 2026 doi:10.1016/j.isci.2026.114877.
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