茶多酚通过肠道微生物脑轴和肠道肝脏轴协同调节减脂机制

摘要(中文译文)

肥胖的发生和发展与肠道生态失调、代谢紊乱和神经内分泌信号密切相关。茶多酚可以通过重塑肠道微生物群来协同调节能量平衡。本综述创新性地提出并系统地论证了茶多酚通过调节肠道微生物群代谢物（如短链脂肪酸和次生胆汁酸）介导肠脑轴和肠肝轴之间的交叉对话和协同作用，从而构建了一个多维相互作用的脂肪减少网络。它侧重于这些代谢物的协同机制，可以抑制中枢食欲（“节流”），同时激活肝脏AMPK和其他途径促进脂肪酸氧化（“开源”），揭示了茶多酚多靶点和系统作用的深层原理，为基于“肠脑肝”整合轴的精准营养干预提供了新的理论基础和实践路径。

Abstract

The occurrence and development of obesity are closely related to intestinal dysbiosis, metabolic disorders, and neuroendocrine signals. Tea polyphenols can be the key to synergistically regulating energy balance by reshaping the gut microbiota. This review innovatively proposes and systematically demonstrates that tea polyphenols mediate the cross-dialogue and synergy between the gut-brain axis and the gut-liver axis by modulating gut microbiota metabolites (such as short-chain fatty acids and secondary bile acids), thereby constructing a multi-dimensional interaction fat reduction network. It focuses on the synergistic mechanism of such metabolites that can inhibit central appetite ("throttling") while activating liver AMPK and other pathways to promote fatty acid oxidation ("open source"), revealing the deep principle of multi-target and systematic action of tea polyphenols, and providing a new theoretical basis and practical path for precision nutrition intervention based on the "gut-brain-liver" integration axis.

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