漂浮休息（限制性环境刺激疗法）治疗慢性疼痛和相关共病的范围综述
A Scoping Review of Flotation-REST (Restricted Environmental Stimulation Therapy) for Chronic Pain and Associated Comorbidities.
摘要(中文译文)
漂浮限制性环境刺激疗法（flotation-REST）是一种用于慢性疼痛的新型非药物干预手段。既往综述已探讨过漂浮REST对其他结局的影响，但尚未有以慢性疼痛为中心的全面综述。旨在描述评估漂浮REST用于慢性疼痛及相关共病（包括心理、生理和生物标志物结局）的研究范围、广度和性质。对研究设计或实施场所不设限制。排除动物研究、非英文发表的研究以及评估结局超出本综述范围的研究。检索了Ovid MEDLINE、Cochrane Library、Embase和PsycINFO，检索时间自建库至2025年1月。筛选了相关研究和综述的参考文献列表。两名评价者独立筛选标题、摘要和全文。一名评价者提取数据。提取变量包括研究设计、人群、对照、结局和干预参数。采用Cochrane RoB 2工具评估随机试验的偏倚风险。共纳入8项研究（6项随机对照试验和2项单臂前后对照研究），涉及401名参与者。各研究一致报告疼痛强度和频率改善、疼痛部位减少以及疼痛耐受力和检测能力提高。大多数研究中焦虑和抑郁显著减轻。部分研究报告睡眠质量和入睡潜伏期改善，但其他研究报告无获益。应激水平一致下降，乐观情绪增加。生理学结局结果不一。生物标志物分析显示治疗后3-甲氧基-4-羟基苯乙二醇（MHPG，去甲肾上腺素代谢产物）降低，催乳素升高。研究设计、干预方案、结局指标和随访时长方面存在相当大的异质性，无法进行荟萃分析。漂浮REST在减轻慢性疼痛和改善心理健康方面似乎具有前景。生理学和生物标志物效应仍不明确。需要采用标准化干预和纵向随访的高质量随机试验来确认其疗效、可持续性和临床适用性。
Abstract
Flotation-Restricted Environmental Stimulation Therapy (flotation-REST) is a novel nonpharmacologic intervention for chronic pain. Previous reviews have examined the effects of flotation-REST on other outcomes, but a comprehensive review centered on chronic pain has not been conducted. To describe the extent, range, and nature of research evaluating flotation-REST for chronic pain and associated comorbidities, including psychological, physiological, and biomarker outcomes. No restrictions were placed on study design or setting. Studies conducted in animals, not published in English, or assessing outcomes outside the scope of the review were excluded. Ovid MEDLINE, the Cochrane Library, Embase, and PsycINFO were searched from inception to January 2025. Reference lists of relevant studies and reviews were screened. Two reviewers independently screened titles, abstracts, and full texts. One reviewer extracted data. Variables included study design, population, controls, outcomes, and intervention parameters. Risk of bias for randomized trials was assessed using the Cochrane RoB 2 tool. Eight studies (6 randomized controlled trials, and 2 single-arm pre/post) comprising 401 participants met inclusion criteria. Studies consistently reported improvements in pain intensity and frequency, fewer pain locations, and greater pain tolerance and detection. Anxiety and depression were substantially reduced in most studies. Sleep quality and latency improved in some studies, though others reported no benefit. Stress consistently declined, and optimism increased. Physiological outcomes were variable. Biomarker analysis demonstrated a post-treatment reduction in 3 methoxy-4-hydroxyphenylethyleneglycol (MHPG), a norepinephrine metabolite, and increased prolactin. Considerable heterogeneity in study designs, intervention protocols, outcome measures, and follow-up duration precluded meta-analysis. Flotation-REST appears promising for reducing chronic pain and enhancing psychological well-being. Physiological and biomarker effects remain unclear. High-quality randomized trials with standardized interventions and longitudinal follow-up are needed to confirm efficacy, sustainability, and clinical applicability.
如何引用
AMA
Sam J Stuart, Lizeth K Achury, Matthew Kline, Matthew J Bair. A Scoping Review of Flotation-REST (Restricted Environmental Stimulation Therapy) for Chronic Pain and Associated Comorbidities.. Journal of pain research. 2026; doi:10.2147/JPR.S565238.
APA
Sam J Stuart, Lizeth K Achury, Matthew Kline, Matthew J Bair (2026). A Scoping Review of Flotation-REST (Restricted Environmental Stimulation Therapy) for Chronic Pain and Associated Comorbidities.. Journal of pain research. https://doi.org/10.2147/JPR.S565238
GB/T 7714
Sam J Stuart, Lizeth K Achury, Matthew Kline, Matthew J Bair. A Scoping Review of Flotation-REST (Restricted Environmental Stimulation Therapy) for Chronic Pain and Associated Comorbidities.[J]. Journal of pain research, 2026 doi:10.2147/JPR.S565238.
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