线粒体：连接运动与增强心脏功能的中心枢纽
Mitochondria: the central hub linking exercise to enhanced cardiac function.
摘要(中文译文)
久坐生活方式是心血管疾病发生和发展的重要危险因素，而心血管疾病仍是全球发病率和死亡率的主要原因之一。除诱导内皮功能障碍外，长期久坐模式还会触发慢性炎症并破坏内源性抗氧化防御，导致心肌细胞线粒体功能障碍，进而损害心脏健康。相反，规律体育锻炼是一种有效的生活方式干预措施，可减轻久坐相关的心脏损伤并改善心脏功能。线粒体作为调控细胞存活与死亡的核心细胞器，被认为在介导运动的心脏保护效应中发挥关键作用。然而，这些益处背后的精确线粒体机制仍未完全阐明。本综述旨在总结当前关于运动如何调控心脏线粒体功能的证据，特别关注将线粒体呼吸、动力学、钙稳态、炎症信号传导和氧化应激与心脏健康联系起来的最新进展。我们进一步提出，运动诱导的线粒体功能改善构成其心脏保护效应的核心机制。通过比较久坐和运动条件下的线粒体改变，我们为生活方式行为如何塑造心脏健康提供了更清晰的机制视角。此外，本文还讨论了将线粒体定位为运动诱导心脏保护关键靶点的信号通路。
Abstract
Sedentary lifestyle is a major risk factor for the occurrence and development of cardiovascular disease, which remains one of the leading contributors to global morbidity and mortality. Beyond inducing endothelial dysfunction, prolonged sedentary patterns trigger chronic inflammation and disrupt endogenous antioxidant defenses, resulting in mitochondrial dysfunction in cardiomyocytes and subsequent impairment of cardiac health. In contrast, regular physical exercise serves as an effective lifestyle intervention that mitigates sedentary-related cardiac damage and improves cardiac function. Mitochondria, as central organelles governing cellular survival and death, are thought to play a pivotal role in mediating the cardioprotective effects of exercise. However, the precise mitochondrial mechanisms underlying these benefits remain incompletely defined. This review aims to summarize current evidence on how exercise regulates mitochondrial function in the heart, with particular emphasis on recent advances linking mitochondrial respiration, dynamics, calcium homeostasis, inflammatory signaling, and oxidative stress to cardiac health. We further propose that exercise-induced improvements in mitochondrial function constitute a core mechanism underlying its cardioprotective effects. By comparing mitochondrial alterations under sedentary and exercise conditions, we provide a clearer mechanistic perspective on how lifestyle behaviors shape cardiac health. Furthermore, this paper also discusses signaling pathways that position mitochondria as key targets of exercise-induced cardiac protection.
如何引用
AMA
Jiaqin Cai, Tutu Wang, Shunchang Li. Mitochondria: the central hub linking exercise to enhanced cardiac function.. Frontiers in physiology. 2026; doi:10.3389/fphys.2026.1747133.
APA
Jiaqin Cai, Tutu Wang, Shunchang Li (2026). Mitochondria: the central hub linking exercise to enhanced cardiac function.. Frontiers in physiology. https://doi.org/10.3389/fphys.2026.1747133
GB/T 7714
Jiaqin Cai, Tutu Wang, Shunchang Li. Mitochondria: the central hub linking exercise to enhanced cardiac function.[J]. Frontiers in physiology, 2026 doi:10.3389/fphys.2026.1747133.
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