基于细胞外囊泡的癌症精准医学的进展

摘要(中文译文)

近年来，癌症精准医学激发了极大的研究兴趣。癌症治疗中一个新兴领域利用细胞外囊泡（EVs），这是一种天然纳米颗粒，目前已被认为是细胞间通讯的关键参与者。凭借其靶向潜力以及固有的分子运输能力，EVs在药物递送领域展现出巨大前景。靶向肿瘤治疗旨在精准命中癌症的“靶心”，同时避免传统治疗策略相关的脱靶效应。然而，癌细胞的动态特性限制了仅基于癌症抗原的治疗效果。肿瘤微环境是癌症发生和进展的重要因素，提供了另一种靶向途径。在本综述中，我们讨论了已在临床前和临床试验中测试过的潜在肿瘤微环境相关抗原。我们还讨论了如何对EVs进行工程化改造，以在多管齐下的癌症治疗中靶向这些抗原。

Abstract

Cancer precision medicine has spurred tremendous research interest in recent years. An emerging field in cancer therapy utilizes extracellular vesicles (EVs), which are natural nanoparticles that are now recognized as key players in intercellular communication. With targeting potential and their inherent ability to transport molecules, EVs demonstrate great promise in the field of drug delivery. Targeted oncotherapy aims to hit the cancer's bull's eye while avoiding off-target effects associated with traditional treatment strategies. However, the dynamic nature of cancer cells limits the effectiveness of treatment based solely on cancer antigens. The tumour microenvironment is an important factor in cancer development and progression, providing yet another means to target. In this review, we discuss potential tumour microenvironment-associated antigens that have been tested in preclinical and clinical trials. We also discuss how EVs could be engineered to target these antigens in a multi-armed cancer therapy.

如何引用