肝细胞癌中的代谢重编程：免疫逃避机制和治疗意义
Metabolic reprogramming in hepatocellular carcinoma: mechanisms of immune evasion and therapeutic implications.
摘要(中文译文)
肝细胞癌（HCC）是全球癌症相关死亡的主要原因之一，晚期患者的治疗选择有限。代谢重编程是癌症的一个标志性特征，使肿瘤细胞能够适应恶劣的肿瘤微环境（TME）并逃避免疫监视。本综述涉及代谢重编程在HCC中的作用，重点关注葡萄糖、脂质和氨基酸代谢的失调及其对免疫逃逸的影响。文中讨论了关键代谢途径，如Warburg效应、脂肪酸合成和谷氨酰胺分解，以及它们对肿瘤相关巨噬细胞（TAMs）和免疫细胞功能的影响。靶向这些代谢改变是一种有前景的治疗策略，可增强免疫治疗疗效并改善HCC患者的预后。
Abstract
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with limited treatment options for advanced stages. Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to adapt to the harsh tumor microenvironment (TME) and evade immune surveillance. This review involves the role of metabolic reprogramming in HCC, focusing on the dysregulation of glucose, lipid, and amino acid metabolism, and its impact on immune evasion. Key metabolic pathways, such as the Warburg effect, fatty acid synthesis, and glutaminolysis, are discussed, along with their influence on tumor-associated macrophages (TAMs) and immune cell function. Targeting these metabolic alterations presents a promising therapeutic approach to enhance immunotherapy efficacy and improve HCC patient outcomes.
如何引用
AMA
Bocheng Gao, Yan Lu, Xingyue Lai, Xi Xu, Shuhua Gou, Zhida Yang, et al. Metabolic reprogramming in hepatocellular carcinoma: mechanisms of immune evasion and therapeutic implications.. Frontiers in immunology. 2025; doi:10.3389/fimmu.2025.1592837.
APA
Bocheng Gao, Yan Lu, Xingyue Lai, Xi Xu, Shuhua Gou, Zhida Yang, et al (2025). Metabolic reprogramming in hepatocellular carcinoma: mechanisms of immune evasion and therapeutic implications.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2025.1592837
GB/T 7714
Bocheng Gao, Yan Lu, Xingyue Lai, Xi Xu, Shuhua Gou, Zhida Yang, et al. Metabolic reprogramming in hepatocellular carcinoma: mechanisms of immune evasion and therapeutic implications.[J]. Frontiers in immunology, 2025 doi:10.3389/fimmu.2025.1592837.
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