N6甲基腺苷（m6A）在炎症中的修饰：文献计量分析和文献综述

摘要(中文译文)

N6-甲基腺苷（m6A）是真核生物中最丰富的内部信使RNA修饰，通过调控RNA代谢影响多种生理和病理过程。大量研究探讨了m6A在炎症反应和炎症性疾病中的作用。本研究使用VOSviewer和Citespace进行文献计量学分析，系统评估m6A与炎症关联研究的当前格局。文献来源于Web of Science核心合集，特征包括年份、国家/地区、机构、作者、期刊、引用和关键词。根据关键词的文献计量学分析结果，我们对m6A调控炎症的潜在机制进行了叙述性总结。结果表明，m6A调节炎症的关键机制包括细胞凋亡、自噬、氧化应激、免疫细胞功能障碍以及信号通路失调。

Abstract

N6-methyladenosine (m6A) is the most abundant internal messenger RNA modification in eukaryotes, influencing various physiological and pathological processes by regulating RNA metabolism. Numerous studies have investigated the role of m6A in inflammatory responses and inflammatory diseases. In this study, VOSviewer and Citespace were used to perform bibliometric analysis to systematically evaluating the current landscape of research on the association between m6A and inflammation. The literature was sourced from the Web of Science Core Collection, with characteristics including year, country/region, institution, author, journal, citation, and keywords. According to the bibliometric analysis results of keywords, we present a narrative summary of the potential mechanisms by which m6A regulates inflammation. The results showed that the key mechanisms by which m6A modulates inflammation include apoptosis, autophagy, oxidative stress, immune cell dysfunction, and dysregulation of signaling pathways.

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