美国成年人营养状况与甲状腺功能之间的关系：NHANES 2007-2012

摘要(中文译文)

控制性营养状况（CONUT）评分已被开发为可用于评估个体患者营养状况的定量工具。然而，目前关于CONUT评分与甲状腺功能之间关联的研究非常有限。因此，本研究旨在通过评估具有代表性的美国成年人队列来填补这一研究空白。本研究使用国家健康与营养调查（NHANES）数据，将受试者分为营养状况正常组（CONUT评分：0-1）和营养不良组（CONUT评分>1）。通过线性回归模型，采用加权分析策略和亚组分析，探讨CONUT评分与甲状腺功能之间的关联。总体而言，本研究共纳入来自NHANES 2007-2012队列的8082名个体。这些个体的加权平均CONUT评分为0.72（0.02），其中6661名参与者（加权比例：83.12%）属于营养状况正常组，1421名参与者（加权比例：16.88%）属于营养不良组。在调整分析中，发现营养不良的受试者FT4水平升高（β = 0.033；P < 0.001），同时TT3水平降低（β = -3.526；P = 0.01）。本研究数据提供了证据支持较高的CONUT评分（即营养不良）与FT4水平升高及TT3水平降低相关。需要更多研究来进一步探究这些结果的机制驱动因素。

Abstract

Controlled Nutritional Status (CONUT) scores have been developed as quantitative tools that can be employed to gauge the nutritional status of individual patients. However, there has been very little research investigating the association between these CONUT scores and the function of the thyroid. As such, the present study was designed to address this research gap through the evaluation of a representative cohort of American adults. National Health and Nutrition Examination Survey (NHANES) data were herein used to separate subjects into those with normal nutritional status (CONUT score: 0-1) from those who were malnourished (CONUT scores > 1). Associations between these CONUT scores and the function of the thyroid were investigated through linear regression modeling, employing weighted analytical strategies and subgroup analyses. Overall, 8082 individuals from the NHANES 2007-2012 cohort were enrolled in this analysis. The weighted mean CONUT score for these individuals was 0.72 (0.02), with 6661 participants (weighted proportion: 83.12%) falling within the normal nutritional status group and 1421 participants (weighted proportion: 16.88%) within the malnourished group. In adjusted analyses, subjects who were malnourished were found to present with an increase in FT4 levels ( = 0.033; < 0.001 together with reduced TT3 levels ( = -3.526; = 0.01). The present data offer evidence in support of higher CONUT scores, which correspond to malnutrition, being related to increases in FT4 levels together with reductions in TT3 levels. More studies will be crucial to further probe the mechanistic drivers of these results.

如何引用