细菌合成生物学：新药发现的工具

摘要(中文译文)

细菌合成生物学为彻底革新药物发现过程提供了强大的工具。这些工具可用于生成具有增强生物活性与选择性的新型细菌药物化合物，或构建基因修饰微生物作为活体药物。本综述概述了当前用于新药发现的细菌合成生物学工具的最新进展。作者讨论了这些工具的应用，包括生物信息学工具、CRISPR工具、工程化细菌转录调节因子以及合成生物传感器在新药发现中的应用。此外，作者介绍了将噬菌体重编程为活体药物以对抗耐药病原体的最新进展。利用细菌合成生物学工具进行药物发现的领域正在迅速发展。然而，在开发可靠且稳健的细菌工程方法方面仍存在挑战。合成生物学的进一步进展有望加速药物发现，促进针对各种疾病的新型治疗方法的开发。

Abstract

Bacterial synthetic biology has provided powerful tools to revolutionize the drug discovery process. These tools can be harnessed to generate bacterial novel pharmaceutical compounds with enhanced bioactivity and selectivity or to create genetically modified microorganisms as living drugs. This review provides a current overview of the state-of-the-art in bacterial synthetic biology tools for novel drug discovery. The authors discuss the application of these tools including bioinformatic tools, CRISPR tools, engineered bacterial transcriptional regulators, and synthetic biosensors for novel drug discovery. Additionally, the authors present the recent progress on reprogramming bacteriophages as living drugs to fight against antibiotic-resistant pathogens. The field of using bacterial synthetic biology tools for drug discovery is rapidly advancing. However, challenges remain in developing reliable and robust methods to engineer bacteria. Further advancements in synthetic biology hold promise to speed up drug discovery, facilitating the development of novel therapeutics against various diseases.

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