阿立哌唑引起的强迫症症状

摘要(中文译文)

阿立哌唑是一种新型抗精神病药，作为多巴胺部分激动剂具有独特的药理学特征。它被用于治疗精神分裂症和双相情感障碍。这种新型抗精神病药的锥体外系副作用发生率低、代谢变化少，且对血清催乳素浓度无显著不良影响。此外，它不像其他非典型抗精神病药那样与显著体重增加相关。因此，当其他抗精神病药引起这些不良事件时，换用阿立哌唑并不少见。强迫症状是少数第二代抗精神病药的不良后遗症。根据病例报告，在第二代抗精神病药中，氯氮平、奥氮平和利培酮是与这些后遗症最相关的药物。最近，少量病例报告提示阿立哌唑可导致强迫症状的出现。我们报告一例在给予阿立哌唑后出现类似意外不良反应的病例。关键词：阿立哌唑，第二代抗精神病药，强迫症状（OCS）。

Abstract

Aripiprazole is a novel antipsychotic with a unique pharmacological profile as a dopamine partial agonist. It is indicated for treatment of schizophrenia and bipolar disorder. This new antipsychotic has low rate of extrapyramidal side effects, metabolic changes and no significant adverse effect on serum prolactin concentration. In addition,it is not associated with significant weight gain like other atypical antipsychotics. As a reason, when other antipsychotics cause these adverse events, it's not uncommon to switch to Aripiprazole. Obsessive compulsive symptoms have been untoward sequel of a few second-generation antipsychotics. Among the second generation antipsychotics Clozapine, Olanzapine, and Risperidone are the most prominent agents associated with these sequelae, according to case reports. More recently, a handful of case reports indicated development of Obsessive-compulsive symptoms with Aripiprazole. We report a case that exhibited similar unexpected adverse effects after administration of Aripiprazole. Keywords: Aripiprazole, Second generation antipsychotics, Obsessive-compulsive symptoms (OCS).

如何引用