肿瘤坏死因子受体相关因子6通过促进AKT泛素化和磷酸化促进人类癌症的恶性行为
Tumor necrosis factor receptor-associated factor 6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation.
摘要(中文译文)
肿瘤坏死因子受体相关因子6（TRAF6）已被发现在多种癌症中参与癌变过程。然而，TRAF6在癌症中的确切作用尚未得到广泛研究，在很大程度上仍属未知。在本研究中，我们旨在探讨TRAF6在癌症中的生物学功能及其潜在的分子机制。在口腔癌和乳腺癌中均观察到肿瘤低分化与TRAF6表达状态之间呈正相关。TRAF6过表达促进肿瘤细胞增殖、迁移及G /G期向S期转换。肿瘤坏死因子受体相关因子6介导的AKT泛素化及随后的磷酸化在调控肿瘤细胞恶性行为中发挥重要作用。体内给予TRAF6治疗可促进肿瘤生长，而给予E3连接酶缺陷型TRAF6突变体则无此作用。我们的研究结果表明，TRAF6通过促进AKT泛素化和磷酸化参与人类癌症的恶性行为。因此，TRAF6可作为癌症的治疗靶点。
Abstract
Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been found to be involved in carcinogenesis in multiple cancers. However, the precise role of TRAF6 in cancer has not been extensively investigated and remains largely unknown. In this study, we aimed to investigate the biological function of TRAF6 and its underlying molecular mechanisms in cancer. A positive correlation between poor tumor differentiation and TRAF6 expression status was observed in both oral cancer and breast cancer. Overexpression of TRAF6 promoted proliferation, migration, and G /G to S phase transition in tumor cells. Tumor necrosis factor receptor-associated factor 6-mediated AKT ubiquitination and subsequent phosphorylation played an essential role in the control of tumor cell malignant behavior. In vivo treatment with TRAF6, but not the E3 ligase deficient TRAF6 mutant, facilitated tumor growth. Our findings indicate that TRAF6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation. Therefore, TRAF6 could serve as a therapeutic target in cancers.
如何引用
AMA
Jianbo Shi, Zengying Liu, Qin Xu. Tumor necrosis factor receptor-associated factor 6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation.. Cancer science. 2019; doi:10.1111/cas.14012.
APA
Jianbo Shi, Zengying Liu, Qin Xu (2019). Tumor necrosis factor receptor-associated factor 6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation.. Cancer science. https://doi.org/10.1111/cas.14012
GB/T 7714
Jianbo Shi, Zengying Liu, Qin Xu. Tumor necrosis factor receptor-associated factor 6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation.[J]. Cancer science, 2019 doi:10.1111/cas.14012.
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