表观遗传记忆与成瘾的机制
Mechanisms of epigenetic memory and addiction.
摘要(中文译文)
细胞身份和功能的表观遗传调控至少部分是通过DNA和组蛋白共价修饰的改变来实现的。近年来，在理解这些共价修饰如何影响细胞身份和功能方面已取得很大进展。尽管取得了这些进展，表观遗传因素是否以及如何促进记忆形成仍知之甚少。在这篇综述中，我们讨论了在阐明学习和记忆的表观遗传机制方面的最新进展，主要集中在DNA层面，并展望了它们在奖赏记忆和药物成瘾发展中的潜在意义。
Abstract
Epigenetic regulation of cellular identity and function is at least partly achieved through changes in covalent modifications on DNA and histones. Much progress has been made in recent years to understand how these covalent modifications affect cell identity and function. Despite the advances, whether and how epigenetic factors contribute to memory formation is still poorly understood. In this review, we discuss recent progress in elucidating epigenetic mechanisms of learning and memory, primarily at the DNA level, and look ahead to discuss their potential implications in reward memory and development of drug addiction.
如何引用
AMA
Luis M Tuesta, Yi Zhang. Mechanisms of epigenetic memory and addiction.. The EMBO journal. 2014; doi:10.1002/embj.201488106.
APA
Luis M Tuesta, Yi Zhang (2014). Mechanisms of epigenetic memory and addiction.. The EMBO journal. https://doi.org/10.1002/embj.201488106
GB/T 7714
Luis M Tuesta, Yi Zhang. Mechanisms of epigenetic memory and addiction.[J]. The EMBO journal, 2014 doi:10.1002/embj.201488106.
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