[冠心病患者动脉粥样硬化斑块损伤的实验室诊断：PAPP-A（文献综述）]

摘要(中文译文)

血管炎症是动脉粥样硬化进程进展以及破坏性斑块变化形成的主要致病因素。目前正在积极寻找能够在急性冠脉综合征发展早期进行诊断的标志物。本文讨论了炎症标志物及内源性破坏标志物在动脉粥样硬化斑块不稳定性发展中的作用。妊娠相关血浆蛋白A（PAPP-A）是其最具前景的标志物，可用于对冠心病心血管并发症进行风险分层并评估其预后。

Abstract

Vascular inflammation is a major pathogenetic factor for the progression of an atherosclerotic process and for the development of destructive plaque changes. Now an active search is under way for markers to diagnose acute coronary syndrome at the early stage of development. The paper discusses the role of markers of inflammation and endogenous destruction in the development of atherosclerotic plaque instability. Pregnancy-associated plasma protein A (PAPP-A) is its most promising marker. It may be used to stratify the risk of cardiovascular complications in coronary heart disease and to assess their prognosis.

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