过敏性鼻炎与哮喘之间的联系：抗白三烯药物是否有作用？

摘要(中文译文)

变应性鼻炎和哮喘均为慢性异质性疾病，两者在患病率、医疗费用及生活质量方面的社会成本上存在流行病学重叠。二者均为炎症性疾病，具有相似的病理生理机制，并共享部分治疗方法。然而，每种疾病均有一系列各自的治疗手段用于控制这些特应性疾病，从吸入性糖皮质激素、β(2)受体激动剂和抗组胺药到较新的基于单克隆抗体的治疗。本文综述了变应性鼻炎与哮喘的共同组成部分，并审视了近期支持抗白三烯药物作为减轻这两种疾病症状的有效药物的证据。

Abstract

Allergic rhinitis and asthma are both chronic heterogeneous disorders, with an overlapping epidemiology of prevalence, health care costs and social costs in quality of life. Both are inflammatory disorders with a similar pathophysiology, and both share some treatment approaches. However, each disorder has an array of treatments used separately in controlling these atopic disorders, from inhaled corticosteroids, beta(2)-agonists and antihistamines to newer monoclonal antibody-based treatments. The present article reviews the shared components of allergic rhinitis and asthma, and examines recent evidence supporting antileukotrienes as effective agents in reducing the symptoms of both diseases.

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