REM行为障碍（RBD）可能是儿童发作性睡病的首发症状之一
REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.
摘要(中文译文)
超过三分之一的成年发作性睡病-猝倒患者会出现快速眼动（REM）睡眠行为障碍（RBD），而儿童期RBD极为罕见。我们报告了两例发作性睡病-猝倒女童（分别为9岁和7岁），其中RBD是该病的首发症状之一。通过夜间视频多导睡眠监测（v-PSG）发现了RBD的并存，并通过多次睡眠潜伏期试验（MSLT）中睡眠潜伏期缩短和多次睡眠始发REM期（SOREMs）确诊为发作性睡病。两名女童均为人类白细胞抗原（HLA）-DQB1*0602阳性，且其脑脊液（CSF）下丘脑分泌素水平（Hcrt-1）极低。
Abstract
More than one in three adult patients suffering from narcolepsy-cataplexy experience rapid eye movement (REM) behavior disorder (RBD), while RBD in childhood is extremely rare. We present the cases of two girls (aged 9 and 7 years old) with narcolepsy-cataplexy, in whom RBD was one of the first symptoms of the disease. The coincidence of RBD was seen by nocturnal video-polysomnography (v-PSG), and narcolepsy was diagnosed from short sleep latency and multiple sleep onset REMs (SOREMs) during a multiple sleep latency test (MSLT). Both girls were human leukocyte antigen (HLA)-DQB1 *0602 positive, and their cerebrospinal fluid (CSF) hypocretin level (Hcrt-1) was extremely low.
如何引用
AMA
Sona Nevsimalova, Iva Prihodova, David Kemlink, Ling Lin, Emmanuel Mignot. REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.. Sleep medicine. 2007; doi:10.1016/j.sleep.2006.11.018.
APA
Sona Nevsimalova, Iva Prihodova, David Kemlink, Ling Lin, Emmanuel Mignot (2007). REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.. Sleep medicine. https://doi.org/10.1016/j.sleep.2006.11.018
GB/T 7714
Sona Nevsimalova, Iva Prihodova, David Kemlink, Ling Lin, Emmanuel Mignot. REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.[J]. Sleep medicine, 2007 doi:10.1016/j.sleep.2006.11.018.
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