西尼罗病毒与昆津病毒之间的关系

摘要(中文译文)

直到最近，西尼罗（WN）病毒和昆津（KUN）病毒一直被归类为黄病毒属中不同的型别。然而，对这两种病毒分离株的遗传学和抗原性研究表明，它们之间的关系更为复杂。为了更好地界定这种关系，我们对来自不同地理区域的32株KUN病毒分离株和28株WN病毒分离株进行了序列分析，其中包括来自纽约近期暴发疫情的一株WN分离株。序列比较显示，来自澳大利亚的KUN病毒分离株紧密聚集，而WN病毒分离株则表现出显著的遗传分歧，并可分为四个不同的组。来自澳大利亚的KUN病毒分离株在抗原性上同源，且与WN分离株及一株马来西亚KUN病毒不同。我们的结果表明，KUN病毒和WN病毒构成了一组密切相关的病毒，可依据遗传学和抗原性分析将其区分为不同的亚组。

Abstract

Until recently, West Nile (WN) and Kunjin (KUN) viruses were classified as distinct types in the Flavivirus genus. However, genetic and antigenic studies on isolates of these two viruses indicate that the relationship between them is more complex. To better define this relationship, we performed sequence analyses on 32 isolates of KUN virus and 28 isolates of WN virus from different geographic areas, including a WN isolate from the recent outbreak in New York. Sequence comparisons showed that the KUN virus isolates from Australia were tightly grouped but that the WN virus isolates exhibited substantial divergence and could be differentiated into four distinct groups. KUN virus isolates from Australia were antigenically homologous and distinct from the WN isolates and a Malaysian KUN virus. Our results suggest that KUN and WN viruses comprise a group of closely related viruses that can be differentiated into subgroups on the basis of genetic and antigenic analyses.

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